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Engineered clostridium butyricum-pmtl007-GLP-1

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Key Research and Development Program of China and 1 more
  • Animals1

Outcomes

4

Inflammation

downin mice1

1 study

  1. Engineered clostridium butyricum-pmtl007-GLP-1 decreases inflammation in mice.

    “C. butyricum-GLP-1 reduced misfolded α-synuclein (α-syn), prevented dopaminergic (DAergic) neuron loss, mitigated neuroinflammation”

    AnimalsPrnp-SNCA*A53T transgenic mouse model of PD

    Engineered Clostridium butyricum-pMTL007-GLP-1 Delays Neurodegeneration in Prnp-SNCA*A53T Transgenic Mice Model by Suppressing Astrocyte Senescence

    Probiotics and antimicrobial proteins8 Jul 2025

More on Inflammation

Oxidative stress and ROS signalling

downin mice1

1 study

  1. Engineered clostridium butyricum-pmtl007-GLP-1 decreases oxidative stress and ROS signalling in mice.

    “C. butyricum-GLP-1 mitigated oxidative stress-induced senescence by regulating the Nrf2/HO-1 axis and enhancing antioxidant efficacy.”

    AnimalsPrnp-SNCA*A53T transgenic mouse model of PD

    Engineered Clostridium butyricum-pMTL007-GLP-1 Delays Neurodegeneration in Prnp-SNCA*A53T Transgenic Mice Model by Suppressing Astrocyte Senescence

    Probiotics and antimicrobial proteins8 Jul 2025

More on Oxidative stress and ROS signalling

Cellular senescence

downin mice1

1 study

  1. Engineered clostridium butyricum-pmtl007-GLP-1 decreases cellular senescence in mice.

    “reducing the build-up of senescent astrocytes, as evidenced by increased expression of Lamin B1, decreased levels of the senescence biomarker p21”

    AnimalsPrnp-SNCA*A53T transgenic mouse model of PD

    Engineered Clostridium butyricum-pMTL007-GLP-1 Delays Neurodegeneration in Prnp-SNCA*A53T Transgenic Mice Model by Suppressing Astrocyte Senescence

    Probiotics and antimicrobial proteins8 Jul 2025

More on Cellular senescence

Motor function impairments

downin mice1

1 study

  1. Engineered clostridium butyricum-pmtl007-GLP-1 decreases motor function impairments in mice.

    “C. butyricum-GLP-1 reduced misfolded α-synuclein (α-syn), prevented dopaminergic (DAergic) neuron loss, mitigated neuroinflammation, and enhanced motor function impairments in A53T mouse.”

    AnimalsPrnp-SNCA*A53T transgenic mouse model of PD

    Engineered Clostridium butyricum-pMTL007-GLP-1 Delays Neurodegeneration in Prnp-SNCA*A53T Transgenic Mice Model by Suppressing Astrocyte Senescence

    Probiotics and antimicrobial proteins8 Jul 2025

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