ENDOTHELIN-1
- 3 independent labs in 3 countries
- Funders: National Institute of Neurological Disorders and Stroke and 4 more
- 1 of 5 findings with company ties
- Animals1
- Cells1
Outcomes
5Oxidative phosphorylation
downin rats1
1 study
Oxidative phosphorylation
downin rats1
ENDOTHELIN-1 decreases oxidative phosphorylation in rats.
“A similar trend was observed in the rat model of endothelin-1-induced stroke, but reduction of OXPHOS capacity was not limited to FAO.”
Animalsendothelin-1-induced strokebrain
Biochimica et biophysica acta. Molecular basis of diseaseOct 17, 2024
alpha-SMA
upin human cells1
1 study
alpha-SMA
upin human cells1
ENDOTHELIN-1 increases alpha-SMA in human cells.
“Furthermore, ET-1 stimulated contractile protein α-SMA and microglial marker ostepontin in high glucose suggesting a shift toward an ensheathing or microglia-like phenotype.”
Cellsin high glucosebrain microvascular pericytes
Clinical science (London, England : 1979)Aug 6, 2024
p16INK4a
upin human cells1
1 study
p16INK4a
upin human cells1
ENDOTHELIN-1 increases p16INK4a in human cells.
“ET-1 also increased traditional senescence marker p16 protein and pericyte-specific senescence markers, TGFB1i1, PP1CA, and IGFBP7.”
Cellsin diabetes-like conditionsbrain microvascular pericytes1 μmol/L
Clinical science (London, England : 1979)Aug 6, 2024
Cellular senescence
upin human cells1
1 study
Cellular senescence
upin human cells1
ENDOTHELIN-1 increases cellular senescence in human cells.
“ET-1 stimulation increased β-galactosidase accumulation which was prevented by BQ-123.”
Cellsin diabetes-like conditionsbrain microvascular pericytes1 μmol/L
Clinical science (London, England : 1979)Aug 6, 2024
Ferroptosis
upin mouse cells1
1 study
Ferroptosis
upin mouse cells1
ENDOTHELIN-1 induces ferroptosis in mouse cells.
“ET-1 provoked ferroptosis in vitro, the response was nullified by the ETA receptor antagonist BQ123 and mitophagy inducer CsA.”
Cellsin vitro
Biochimica et biophysica acta. Molecular basis of diseaseNov 12, 2023
Funding
3 grants since 2024National Institute on AgingUS$163.6kNational Heart, Lung, and Blood InstituteUS$857k
Contribution of endothelin 1 mediated ischemic vascular dysfunction to Alzheimer's disease
National Institute on AgingOregon Health & Science UniversityUS$55.1k2026
Endothelin-1 inhibits cardiomyocyte proliferation and heart regeneration
National Heart, Lung, and Blood InstituteWeill Medical Coll of Cornell UnivUS$818k2026–2030
National Heart, Lung, and Blood InstituteUniversity of IowaUS$38.9k2025–2028