RNASEK

2 papers5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

2 independent labs in 2 countries

Funders: National Research Foundation of Korea and 4 more

Animals2

Effects

5

Toxic aggregation of circRNAs

downin animals1

1 study

RNASEK prevents toxic aggregation of circRNAs.
“RNASEK, in collaboration with heat shock protein 90 (HSP90), prevents the toxic aggregation of circRNAs in aged organisms.”
Animalswith heat shock protein 90 (HSP90) in stress granules
Ribonuclease κ promotes longevity by preventing age-associated accumulation of circular RNA in stress granules
Molecular cell24 Feb 2026

More on Toxic aggregation of circRNAs

Healthspan

upin worms1

1 study

RNASEK improves healthspan in worms.
“RNASEK is necessary and sufficient for lifespan extension and healthspan maintenance in Caenorhabditis elegans.”
Model organismsshown by overexpression and requirement
Ribonuclease κ promotes longevity by preventing age-associated accumulation of circular RNA in stress granules
Molecular cell24 Feb 2026

Lifespan

upin worms1

1 study

RNASEK extends lifespan in worms.
“RNASEK is necessary and sufficient for lifespan extension and healthspan maintenance in Caenorhabditis elegans.”
Model organismsshown by overexpression and requirement
Ribonuclease κ promotes longevity by preventing age-associated accumulation of circular RNA in stress granules
Molecular cell24 Feb 2026

Embryonic development

is required forin mice1

1 study

RNASEK is required for embryonic development in mice.
“RNASEK regulates lysosomal function via V-ATPase and is required for egg cylinder development in the mouse embryo.”
Animalsshown by knockout
Loss of RNASEK Terminates Egg Cylinder Development by Impairing Lysosomal Function Associated With V-ATPase in Mouse
FASEB journal : official publication of the Federation of American Societies for Experimental Biology15 Dec 2025

Cellular senescence

downin mice1

1 study

RNASEK prevents cellular senescence in mice.
“loss of RNASEK promotes premature senescence of multiple cell lineages, terminating early embryonic development.”
Animalsshown by knockout
Loss of RNASEK Terminates Egg Cylinder Development by Impairing Lysosomal Function Associated With V-ATPase in Mouse
FASEB journal : official publication of the Federation of American Societies for Experimental Biology15 Dec 2025

More on Cellular senescence

Latest

2 in 12 months

Molecular Cell26 Feb

Ribonuclease κ promotes longevity by preventing age-associated accumulation of circular RNA in stress granules

Experiments in wormsMechanisms

FASEB Journal15 Dec

Loss of RNASEK Terminates Egg Cylinder Development by Impairing Lysosomal Function Associated With V-ATPase in Mouse

Experiments in miceLysosome