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Dl-propargylglycine

Dl-propargylglycine has been studied in 1 paper since 2024: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Jun 5, 2024: “Inhibition of endogenous hydrogen sulfide production reduces activation of hepatic stellate cells via the induction of cellular senescence”.

Intervention

1 paper studies it2 more mention it2 findingsUpdated

PubChem

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: China Scholarship Council and 2 more
  • Animals1

What did studies of Dl-propargylglycine find?

2

Studies of Dl-propargylglycine measured 2 outcomes; the most studied are cellular senescence (1 study) and ACTA2 (1).

Cellular senescence

upin rat cells1

1 study

  1. Dl-propargylglycine induces cellular senescence in rat cells.

    “Additionally, the number of β-galactosidase positive senescent HSCs was increased.”

    Cellsin culture-activated rat HSCshepatic stellate cells

    Inhibition of endogenous hydrogen sulfide production reduces activation of hepatic stellate cells via the induction of cellular senescence

    Cell cycle (Georgetown, Tex.)

More on Cellular senescence

ACTA2

downin rat cells1

1 study

  1. Dl-propargylglycine decreases ACTA2 in rat cells.

    “Inhibition of CTH reduced proliferation and expression of fibrotic markers Col1a1 and Acta2 in HSCs.”

    Cellsin culture-activated rat HSCshepatic stellate cells

    Inhibition of endogenous hydrogen sulfide production reduces activation of hepatic stellate cells via the induction of cellular senescence

    Cell cycle (Georgetown, Tex.)

More on ACTA2

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