Gyy 4137

1. Gyy 4137 decreases cellular senescence in rat cells.

   “GYY4137 partially restored the proliferation of senescent HSCs and attenuated the DL-PAG-induced senescent phenotype.”

   Cellsin DL-PAG-treated rat HSCshepatic stellate cells

   Inhibition of endogenous hydrogen sulfide production reduces activation of hepatic stellate cells via the induction of cellular senescence

   Cell cycle (Georgetown, Tex.)·Jun 5, 2024

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1. Gyy 4137 decreases SLC2A1 in rats.

   “Both GLUT1 and GLUT2 expression was increased in the 6- and 12-month groups, and reversed by GYY4137 in the 12-month group.”

   Animalsageingkidneymales

   Ageing-Related Alterations in Renal Epithelial Glucose Transport

   International journal of molecular sciences·Nov 17, 2023

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1. Gyy 4137 decreases SLC5A2 in rats.

   “Increased SGLT1 and SGLT2 expression was observed in the 12-month group, which was reversed by GYY4137.”

   Animalsageingkidneymales

   Ageing-Related Alterations in Renal Epithelial Glucose Transport

   International journal of molecular sciences·Nov 17, 2023

More on SLC5A2

1. Gyy 4137 decreases glomerulosclerosis in rats.

   “The kidney tissue showed mild glomerulosclerosis in the 12-month group, which was diminished by GYY4137.”

   Animalsageingkidneymales

   Ageing-Related Alterations in Renal Epithelial Glucose Transport

   International journal of molecular sciences·Nov 17, 2023

More on Glomerulosclerosis

1. Gyy 4137 decreases blood glucose in rats.

   “Blood sugar level and HOMA-IR index increased in the 12-month group, and were partially improved by GYY4137.”

   Animalsageingmales

   Ageing-Related Alterations in Renal Epithelial Glucose Transport

   International journal of molecular sciences·Nov 17, 2023

More on Blood glucose