Dihydronicotinamide riboside
- 2 independent labs in 2 countries
- Funders: Cornell University and 5 more
- 3 of 7 findings with company ties
- Animals2
Outcomes
7Obesity
downin mice1
1 study
Obesity
downin mice1
Dihydronicotinamide riboside decreases obesity in mice.
“NRH mitigates high-fat diet-induced metabolic complications when used as a preventive or as a treatment strategy”
Animalshigh-fat diet-induced metabolic complications100 mg/(kg*day)
Nature communications25 Mar 2026
Lipid and ceramide metabolism
upin mice1
1 study
Lipid and ceramide metabolism
upin mice1
Dihydronicotinamide riboside increases lipid and ceramide metabolism in mice.
“increased hepatic expression of lipid catabolism genes and fat redistribution”
Animalshigh-fat dietliver100 mg/(kg*day)
Nature communications25 Mar 2026
Glucose tolerance
upin mice1
1 study
Glucose tolerance
upin mice1
Dihydronicotinamide riboside improves glucose tolerance in mice.
“NRH mitigates high-fat diet-induced metabolic complications when used as a preventive or as a treatment strategy, including improvements in glucose tolerance”
Animalshigh-fat diet-induced metabolic complications100 mg/(kg*day)
Nature communications25 Mar 2026
Ferroptosis
downin mice1
1 study
Ferroptosis
downin mice1
Dihydronicotinamide riboside inhibits ferroptosis in mice.
“inhibiting oxidative stress and lipid peroxidation via modulation of ferroptosis-related pathways”
Animalscochlea
Free radical biology & medicine25 Feb 2026
Cellular senescence
downin mice1
1 study
Cellular senescence
downin mice1
Dihydronicotinamide riboside decreases cellular senescence in mice.
“inhibiting oxidative stress and lipid peroxidation via modulation of ferroptosis-related pathways, ultimately mitigating cochlear cellular senescence.”
Animalscochlea
Free radical biology & medicine25 Feb 2026
SIRT3
upin mice1
1 study
SIRT3
upin mice1
Dihydronicotinamide riboside activates SIRT3 in mice.
“NRH activated Sirt3, thereby inhibiting oxidative stress and lipid peroxidation via modulation of ferroptosis-related pathways, ultimately mitigating cochlear cellular senescence.”
Animalscochlea
Free radical biology & medicine25 Feb 2026
Age-related hearing loss
downin mice1
1 study
Age-related hearing loss
downin mice1
Dihydronicotinamide riboside decreases age-related hearing loss in mice.
“NRH administration ameliorated ARHL in C57BL/6 mice, as evidenced by improved auditory thresholds and elevated cochlear NAD+ levels.”
Animalsagingcochlea125 mg/kg
Free radical biology & medicine25 Feb 2026