Diet normalization

1. Diet normalization protects against mitochondrial fission and fusion in mice.

   “Mostly, these alterations were prevented in the DN group, while, in CR, this was only the case for a few parameters.”

   Animalsmaternal preconception diet normalization versus HF/HS in female F1 oocytesoocytefemales

   Preconception Diet Interventions in Obese Outbred Mice and the Impact on Female Offspring Metabolic Health and Oocyte Quality

   International journal of molecular sciences·Feb 13, 2024

More on Mitochondrial fission and fusion

1. Diet normalization improves oocyte developmental competence in mice.

   “The in vitro developmental capacity of the oocytes was improved but did not reach the levels of the CTRL_CTRL mice.”

   AnimalsWestern-type diet-induced obese micead libitum control dietoocyte4 weeksfemales

   Obese outbred mice only partially benefit from diet normalization or calorie restriction as preconception care interventions to improve metabolic health and oocyte quality

   Human reproduction (Oxford, England)·Nov 8, 2022

1. Diet normalization decreases body weight in mice.

   “HF_CTRL mice already showed restored body weight, serum lipid profile and glucose tolerance, similar to the CTRL_CTRL group after only 2 weeks of PCCI (P < 0.05 compared with HF_HF)”

   AnimalsWestern-type diet-induced obese micead libitum control diet2 weeksfemales

   Obese outbred mice only partially benefit from diet normalization or calorie restriction as preconception care interventions to improve metabolic health and oocyte quality

   Human reproduction (Oxford, England)·Nov 8, 2022