Deuterium oxide

Deuterium oxide has been studied in 3 papers since 2016: 1 observational study in people, 1 in animals, 1 in cells. Its furthest trials in people are at phase 2. The newest paper, Sep 17, 2022: “Dietary intake of deuterium oxide decreases cochlear metabolism and oxidative stress levels in a mouse model of age-related hearing loss”.

Intervention Phase 2

3 papers study it36 more mention it7 findingsUpdated Sep 17, 2022

PubChem ChEBI MeSH

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“the consumption of heavy water and the lifestyles generated by the production of coffee and sugar cane prolong life and good old age”

Natural and cultural longevity zones from an anthropological and geographical viewpointJournal of population ageing2022doi:10.1007/s12062-022-09370-w

2 of its findings point the other way.

4 independent labs in 3 countries
2 findings against
4 trials, none about aging

Funders: California Institute for Regenerative Medicine and 4 more

Humans1
Animals1
Cells1

What did lifespan studies of deuterium oxide find?

DrugAge

DrugAge records 4 results from 1 paper: 4 in D. melanogaster. Average lifespan is the mean or the median, as each paper reports it.

What did studies of deuterium oxide find?

Studies of deuterium oxide measured 7 outcomes; the most studied are NRF2–KEAP1 antioxidant response (1 study), oxidative stress and ROS signaling (1) and hearing threshold (1).

NRF2–KEAP1 antioxidant response

downin mice1

1 study

Deuterium oxide inhibits NRF2–KEAP1 antioxidant response in treated mice.
“Experiments confirmed that the Nrf2/HO-1/glutathione axis was down-regulated in treated mice.”
Animalsin treated mice
Dietary intake of deuterium oxide decreases cochlear metabolism and oxidative stress levels in a mouse model of age-related hearing loss
Redox biologySep 17, 2022

More on NRF2–KEAP1 antioxidant response

Oxidative stress and ROS signaling

downin mice1

1 study

Deuterium oxide decreases oxidative stress and ROS signaling in a mouse model of age-related hearing loss.
“Oxidative stress levels were significantly reduced and in the cochlear duct of treated vs. untreated mice.”
Animalsin a mouse model of age-related hearing losscochlear duct
Dietary intake of deuterium oxide decreases cochlear metabolism and oxidative stress levels in a mouse model of age-related hearing loss
Redox biologySep 17, 2022

More on Oxidative stress and ROS signaling

Hearing threshold

upin mice1

1 study

Deuterium oxide improves hearing threshold in a mouse model of age-related hearing loss.
“lowered hearing thresholds at selected frequencies in treated mice compared to untreated control group”
Animalsin a mouse model of age-related hearing lossdietary supplement10%
Dietary intake of deuterium oxide decreases cochlear metabolism and oxidative stress levels in a mouse model of age-related hearing loss
Redox biologySep 17, 2022

Lifespan

upin humans1

1 study

Deuterium oxide is linked with longer lifespan in the town of El Espinal, municipality of Naolinco, Veracruz.
“the consumption of heavy water and the lifestyles generated by the production of coffee and sugar cane prolong life and good old age”
Humansin the town of El Espinal, municipality of Naolinco, Veracruz
Natural and cultural longevity zones from an anthropological and geographical viewpoint
Journal of population ageingAug 10, 2022

Metabolic consumption and disposal

downin yeast cells1

1 study

Deuterium oxide decreases metabolic consumption and disposal in yeast cells.
“Heavy water substantially suppresses endogenous generation of reactive oxygen species (ROS) and slows the pace of metabolic consumption and disposal.”
Cells
Yeast longevity promoted by reversing aging-associated decline in heavy isotope content
NPJ aging and mechanisms of diseaseFeb 18, 2016

Reactive oxygen species generation

downin yeast cells1

1 study

Deuterium oxide decreases reactive oxygen species generation in yeast cells.
“Heavy water substantially suppresses endogenous generation of reactive oxygen species (ROS)”
Cells
Yeast longevity promoted by reversing aging-associated decline in heavy isotope content
NPJ aging and mechanisms of diseaseFeb 18, 2016

More on Reactive oxygen species generation

Chronological lifespan

upin yeast cells1+85% chronological lifespan

1 study

Deuterium oxide extends chronological lifespan in yeast cells (up to 85% longer chronological lifespan).
“Supplementation of deuterium, a heavy hydrogen isotope, through heavy water (D2O) uptake extends yeast chronological lifespan (CLS) by up to 85%”
Cells
Yeast longevity promoted by reversing aging-associated decline in heavy isotope content
NPJ aging and mechanisms of diseaseFeb 18, 2016

Has deuterium oxide been tested in people?

0 of 4 about aging

Yes: 1 observational study in people have been published, and 4 trials are registered.

In trials

Leukemia
Phase 1/2Results posted1 trial
Leukemia, Lymphocytic, Chronic, B-Cell
Phase 1/2Results posted1 trial
Hyperinsulinism
Phase 1Results posted2 trials
Insulin resistance
Phase 1Results posted2 trials
Metabolic dysfunction-associated steatotic liver disease
Phase 1Results posted2 trials
Prediabetic state
Phase 1Results posted2 trials

All 7

Trial sponsors

Emory University
1 trialPhase 230 people
M.D. Anderson Cancer Center
1 trialPhase 1/230 people
Columbia University
2 trialsPhase 147 people

Funding

2 grants since 2020

National Institute of General Medical Sciences$1.4MNational Institute on Aging$840K

Latest

5 papers in 12 months

Redox BiologySep 27

Dietary intake of deuterium oxide decreases cochlear metabolism and oxidative stress levels in a mouse model of age-related hearing loss

Experiments in miceEar

Paper

Journal of Population AgeingAug 16

Natural and cultural longevity zones from an anthropological and geographical viewpoint

Cohort study in peoplePopulations

Paper

NPJ Aging and Mechanisms of DiseaseFeb 18

Yeast longevity promoted by reversing aging-associated decline in heavy isotope content

Experiments in yeastInterventions

Paper

The American Journal of Clinical NutritionSep 1

Self-selected vegan diet reduced muscle in older adults

Thigh muscle volume fell 0.61 liters on the vegan diet versus 0.01 liters on the omnivorous diet over 12 weeks.Thigh muscle volume fell 0.61 liters on the vegan diet versus 0.01 liters on the omnivorous diet over 12 weeks.

Randomized trial · 72 peopleVegan diet