Daytime sleepiness

5 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

3 independent labs in 1 country

Humans5

Outcomes

Cognitive function

no changein humans1

1 study

Daytime sleepiness has no effect on cognitive function in humans (p > .05).
“ESS showed no independent effect on cognitive performance ( p > .05).”
Humanscognitively normal non-sleepy older adultsn = 186
Associations of Sleepiness Scores and Cognitive Performance in Cognitively Normal Non‐Sleepy Older Adults – Examining for Race and Sex‐specific Differences
AAIC 2025 abstract26 Dec 2025

Associations

NfL

upin humans1

1 study

Daytime sleepiness is associated with NfL in humans (β=0.17, 95% CI=0.05,0.29).
“Daytime sleepiness was associated with lower Aβ 42/40 (β=‐0.13, 95% CI=‐0.25,‐0.01) and higher NfL (β=0.17, 95% CI=0.05,0.29) levels.”
Humans15 years
Sleep patterns in midlife and Alzheimer's disease biomarkers
AAIC 2025 abstract23 Dec 2025