CSP7
CSP7 has been studied in 2 papers since 2023: none in people yet, 2 in animals. The research so far is in animals. The newest paper, Sep 13, 2024: “CSP7 Protects Alveolar Epithelial Cells by Targeting p53-Fibrinolytic Pathways During Lung Injuries”.
- 1 lab in 1 country
- Funders: National Heart, Lung, and Blood Institute and 4 more
- 4 of 7 findings with company ties
- Animals2
What did studies of CSP7 find?
6Studies of CSP7 measured 6 outcomes; the most studied are TP53 (1 study), telomere length (1) and AT2 cell viability (1).
TP53
downin mice1
1 study
TP53
downin mice1
CSP7 decreases TP53 in mice.
“induction of p53, PAI-1, SIAH1, and TRF1; as well as loss of TRF2 and TERT, which were reversed in wild-type mice after treatment with CSP7.”
Animalsbleomycin- or chronic tobacco smoke-induced lung injurytype II alveolar epithelial cells
CSP7 Protects Alveolar Epithelial Cells by Targeting p53-Fibrinolytic Pathways During Lung Injuries
American journal of respiratory cell and molecular biology
Telomere length
upin mice1
1 study
Telomere length
upin mice1
CSP7 increases telomere length in mice.
“showed reduced telomere length; induction of p53, PAI-1, SIAH1, and TRF1; as well as loss of TRF2 and TERT, which were reversed in wild-type mice after treatment with CSP7.”
Animalsbleomycin- or chronic tobacco smoke-induced lung injurytype II alveolar epithelial cells
CSP7 Protects Alveolar Epithelial Cells by Targeting p53-Fibrinolytic Pathways During Lung Injuries
American journal of respiratory cell and molecular biology
AT2 cell viability
upin cells1
1 study
AT2 cell viability
upin cells1
CSP7 improves AT2 cell viability in cells.
“treatment of AECs, AT2 cells, or lung tissue slices from patients with COPD or mice with CS-LI with a seven amino acid caveolin-1 scaffolding domain peptide (CSP7) reduced mucus hypersecretion in AECs and improved AT2 cell viability”
CellsCS-induced lung injury or COPD
Caveolin-1-derived peptide attenuates cigarette smoke-induced airway and alveolar epithelial injury
American journal of physiology. Lung cellular and molecular physiology
Mucus hypersecretion
downin cells1
1 study
Mucus hypersecretion
downin cells1
CSP7 decreases mucus hypersecretion in cells.
“treatment of AECs, AT2 cells, or lung tissue slices from patients with COPD or mice with CS-LI with a seven amino acid caveolin-1 scaffolding domain peptide (CSP7) reduced mucus hypersecretion in AECs”
CellsCS-induced lung injury or COPD
Caveolin-1-derived peptide attenuates cigarette smoke-induced airway and alveolar epithelial injury
American journal of physiology. Lung cellular and molecular physiology
Lung function
upin mice1
1 study
Lung function
upin mice1
CSP7 improves lung function in mice.
“treatment of wild-type mice having CS-LI with CSP7 by intraperitoneal injection or nebulization via airways attenuated mucus hypersecretion, alveolar injury, and significantly improved lung function”
AnimalsCS-induced lung injury
Caveolin-1-derived peptide attenuates cigarette smoke-induced airway and alveolar epithelial injury
American journal of physiology. Lung cellular and molecular physiology
Alveolar injury
downin mice1
1 study
Alveolar injury
downin mice1
CSP7 decreases alveolar injury in mice.
“treatment of wild-type mice having CS-LI with CSP7 by intraperitoneal injection or nebulization via airways attenuated mucus hypersecretion, alveolar injury, and significantly improved lung function”
AnimalsCS-induced lung injury
Caveolin-1-derived peptide attenuates cigarette smoke-induced airway and alveolar epithelial injury
American journal of physiology. Lung cellular and molecular physiology
What acts on CSP7?
1Studies name 1 thing that act on CSP7, most often PLAU (1 study).
PLAU
is required forin mice1
1 study
PLAU
is required forin mice1
PLAU is required for CSP7 in mice.
“whereas uPA-/- mice failed to respond to CSP7 treatment”
Animalsshown by uPA-/- failing to respond to CSP7type II alveolar epithelial cells
CSP7 Protects Alveolar Epithelial Cells by Targeting p53-Fibrinolytic Pathways During Lung Injuries
American journal of respiratory cell and molecular biology