Crocetin

1. Crocetin improves mitochondrial membrane potential and cellular energy state in mouse cells.

   “The chronic treatment of aged astrocytes also showed improved mitochondrial membrane potential and energy state of the cells.”

   Cellsastrocytechronic treatment

   Crocetin Delays Brain and Body Aging by Increasing Cellular Energy Levels in Aged C57BL/6J Mice

   ACS pharmacology & translational science·11 Sep 2024

1. Crocetin increases OXPHOS-linked gene expression in mice.

   “enhanced brain energy level was caused by the upregulation of genes linked to OXPHOS, and their expression was close to that in young mice.”

   Animalshippocampusfour months

   Crocetin Delays Brain and Body Aging by Increasing Cellular Energy Levels in Aged C57BL/6J Mice

   ACS pharmacology & translational science·11 Sep 2024

More on OXPHOS-linked gene expression

1. Crocetin extends lifespan in mice.

   “leading to an increased median life span.”

   Animalsfour months

   Crocetin Delays Brain and Body Aging by Increasing Cellular Energy Levels in Aged C57BL/6J Mice

   ACS pharmacology & translational science·11 Sep 2024

1. Crocetin increases ATP and NAD+ in mice.

   “significantly improved memory behavior, neuromuscular coordination, and ATP and NAD+ levels in the brain and other vital organs”

   Animalsbrain and other vital organsfour months

   Crocetin Delays Brain and Body Aging by Increasing Cellular Energy Levels in Aged C57BL/6J Mice

   ACS pharmacology & translational science·11 Sep 2024

More on ATP and NAD+

1. Crocetin improves memory behavior and neuromuscular coordination in mice.

   “aged mice treated with crocetin for four months displayed significantly improved memory behavior, neuromuscular coordination”

   Animalsfour months

   Crocetin Delays Brain and Body Aging by Increasing Cellular Energy Levels in Aged C57BL/6J Mice

   ACS pharmacology & translational science·11 Sep 2024