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COL11A1-OVEREXPRESSING smsc mini-organoids

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Humans1

Outcomes

2

Cellular senescence

downin mice1

1 study

  1. COL11A1-OVEREXPRESSING smsc mini-organoids decrease cellular senescence in mice.

    “ameliorated cartilage degeneration in DDH mice via regulating cellular senescence”

    Animalsin DDH micecartilage

    Genetically inspired organoids prevent joint degeneration and alleviate chondrocyte senescence via Col11a1-HIF1α-mediated glycolysis-OXPHOS metabolism shift

    Clinical and translational medicine1 Feb 2024

More on Cellular senescence

Cartilage degeneration

downin mice1

1 study

  1. COL11A1-OVEREXPRESSING smsc mini-organoids decrease cartilage degeneration in mice.

    “Col11a1-OE organoids ameliorated cartilage degeneration in DDH mice”

    Animalsin DDH micecartilage

    Genetically inspired organoids prevent joint degeneration and alleviate chondrocyte senescence via Col11a1-HIF1α-mediated glycolysis-OXPHOS metabolism shift

    Clinical and translational medicine1 Feb 2024

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