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COL11A1

Gene

3 papers2 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Humans3

Effects

1

Joint degeneration

downin mice1

1 study

  1. COL11A1 decreases joint degeneration in mice.

    “Col11a1-KO mice demonstrated aggravated joint degeneration and severe OA phenotype.”

    Animalswith induced DDH

    Genetically inspired organoids prevent joint degeneration and alleviate chondrocyte senescence via Col11a1-HIF1α-mediated glycolysis-OXPHOS metabolism shift

    Clinical and translational medicine1 Feb 2024

Associations

1

Developmental dysplasia of hip

upin humans1

1 study

  1. COL11A1 is associated with developmental dysplasia of hip in humans.

    “identified genetic association between COL11A1 locus and DDH with genome-wide association study (GWAS).”

    Humans

    Genetically inspired organoids prevent joint degeneration and alleviate chondrocyte senescence via Col11a1-HIF1α-mediated glycolysis-OXPHOS metabolism shift

    Clinical and translational medicine1 Feb 2024

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