AgingResearch.NewsJoin free

Cl-316,243

Intervention

3 papers12 findings

PubChem

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: American Heart Association and others
  • Animals3

Outcomes

10

Energy expenditure

upin mice2

2 studies

  1. Cl-316,243 increases energy expenditure in mice.

    “Sustained β3-AR treatment resulted in reduced fat mass, increased energy expenditure, increased fatty acid oxidation and mitochondrial activity in adipose depots, improved glucose homeostasis”

    Animalsaged

    Chronic β3-AR stimulation activates distinct thermogenic mechanisms in brown and white adipose tissue and improves systemic metabolism in aged mice

    Aging cellAug 23, 2024

  2. Cl-316,243 increases energy expenditure in mice.

    “Sustained β3-AR treatment resulted in reduced fat mass, increased energy expenditure”

    Animalschronic

    The metabolic benefits of thermogenic stimulation are preserved in aging

    bioRxiv : the preprint server for biologyJul 4, 2024Preprint

Fat mass

downin mice2

2 studies

  1. Cl-316,243 decreases fat mass in mice.

    “Sustained β3-AR treatment resulted in reduced fat mass, increased energy expenditure, increased fatty acid oxidation and mitochondrial activity in adipose depots, improved glucose homeostasis”

    Animalsagedadipose tissue

    Chronic β3-AR stimulation activates distinct thermogenic mechanisms in brown and white adipose tissue and improves systemic metabolism in aged mice

    Aging cellAug 23, 2024

  2. Cl-316,243 decreases fat mass in mice.

    “Sustained β3-AR treatment resulted in reduced fat mass, increased energy expenditure, increased fatty acid oxidation and mitochondrial activity in adipose depots, improved glucose homeostasis”

    Animalschronic

    The metabolic benefits of thermogenic stimulation are preserved in aging

    bioRxiv : the preprint server for biologyJul 4, 2024Preprint

Cognitive function

upin mice1

1 study

  1. Cl-316,243 improves cognitive function in mice.

    “these beneficial changes in microvascular function translated to improved cognitive performance in aged mice.”

    Animals6 weeks

    Chronic β3 adrenergic agonist treatment improves neurovascular coupling responses, attenuates blood-brain barrier leakage and neuroinflammation, and enhances cognition in aged mice

    AgingFeb 19, 2025

Angiogenesis

upin mice1

1 study

  1. Cl-316,243 increases angiogenesis in mice.

    “increased microvascular density in the hippocampus of aged mice.”

    Animalshippocampus6 weeks

    Chronic β3 adrenergic agonist treatment improves neurovascular coupling responses, attenuates blood-brain barrier leakage and neuroinflammation, and enhances cognition in aged mice

    AgingFeb 19, 2025

More on Angiogenesis

Inflammation

downin mice1

1 study

  1. Cl-316,243 decreases inflammation in mice.

    “associated neuroinflammation in the cortex”

    Animalscortex6 weeks

    Chronic β3 adrenergic agonist treatment improves neurovascular coupling responses, attenuates blood-brain barrier leakage and neuroinflammation, and enhances cognition in aged mice

    AgingFeb 19, 2025

More on Inflammation

Blood-brain barrier leakage

downin mice1

1 study

  1. Cl-316,243 decreases blood-brain barrier leakage in mice.

    “CL treatment also attenuated blood-brain barrier leakage and associated neuroinflammation in the cortex”

    Animalscortex6 weeks

    Chronic β3 adrenergic agonist treatment improves neurovascular coupling responses, attenuates blood-brain barrier leakage and neuroinflammation, and enhances cognition in aged mice

    AgingFeb 19, 2025

Neurovascular coupling

upin mice1

1 study

  1. Cl-316,243 improves neurovascular coupling in mice.

    “CL treatment improved neurovascular coupling responses and rescued brain glucose uptake in aged animals.”

    Animals6 weeks

    Chronic β3 adrenergic agonist treatment improves neurovascular coupling responses, attenuates blood-brain barrier leakage and neuroinflammation, and enhances cognition in aged mice

    AgingFeb 19, 2025

Lipid and ceramide metabolism

upin mice1

1 study

  1. Cl-316,243 increases lipid and ceramide metabolism in mice.

    “in white adipose tissue (WAT) depots, CL treatment increased glycerol and lipid de novo lipogenesis (DNL) and turnover”

    Animalsagedwhite adipose tissue

    Chronic β3-AR stimulation activates distinct thermogenic mechanisms in brown and white adipose tissue and improves systemic metabolism in aged mice

    Aging cellAug 23, 2024

More on Lipid and ceramide metabolism

thermogenesis

upin mice1

1 study

  1. Cl-316,243 increases thermogenesis in mice.

    “At the cellular level, CL treatment increased uncoupling protein 1 (UCP1)-dependent thermogenesis in brown adipose tissue (BAT).”

    Animalsbrown adipose tissue

    The metabolic benefits of thermogenic stimulation are preserved in aging

    bioRxiv : the preprint server for biologyJul 4, 2024Preprint

Glucose homeostasis

upin mice1

1 study

  1. Cl-316,243 improves glucose homeostasis in mice.

    “improved glucose homeostasis, and a favorable adipokine profile”

    Animalschronic

    The metabolic benefits of thermogenic stimulation are preserved in aging

    bioRxiv : the preprint server for biologyJul 4, 2024Preprint

Latest

Related