Cellular senescence
downin human cells1
Citrate decreases cellular senescence in human cells.
“citrate exposure delayed human umbilical vein endothelial cell senescence with a decreased percentage of cells stained with senescence-associated β-galactosidase and p21 levels.”
Cellshuman umbilical vein endothelial cells
Aging cell4 Sep 2025
Frailty index
downin mice1
Citrate decreases frailty index in mice.
“citrate decreased the frailty index, increased bone density, and improved maximal grip strength and balance speed in both aged and HFD-fed ApoE-/- mice.”
Animalsin both aged and HFD-fed ApoE-/- mice
Aging cell4 Sep 2025
Atherosclerosis
downin mice1
Citrate decreases atherosclerosis in mice.
“in HFD-fed ApoE-/- mice, it reduced the size of atherosclerotic plaques, decreased the necrotic core area and vulnerability index in aortic root plaques.”
Animalsin HFD-fed ApoE-/- mice
Aging cell4 Sep 2025
Blood pressure
downin mice1
Citrate decreases blood pressure in mice.
“citrate improved the sensitivity to endothelial-dependent vasodilators and lowered blood pressure”
Animalsdietary supplementation
Aging cell4 Sep 2025
Vascular aging
downin mice1
Citrate decreases vascular aging in mice.
“dietary supplementation of citrate delayed vascular aging, as evidenced by maintaining the integrity of elastic fibers and decreasing the level of the aging-related marker, CDKN1A (p21).”
Animalsdietary supplementation
Aging cell4 Sep 2025
In a 10-day experiment, two compounds improved different aspects of muscle function in aged male and female mice with one hindlimb immobilised.In a 10-day experiment, two compounds improved different aspects of muscle function in aged male and female mice with one hindlimb immobilised.
Multi-omics profiling in Drosophila links chromatin regulation to increased ATP, higher NAD-to-NADH ratios, and altered lipid metabolism in aged heads.Multi-omics profiling in Drosophila links chromatin regulation to increased ATP, higher NAD-to-NADH ratios, and altered lipid metabolism in aged heads.