Cholesterol lowering
Cholesterol lowering has been studied in 4 papers since 2022: 1 observational study in people, 1 in animals, 2 reviews; 1 in the past year. The newest paper, Feb 18, 2026: “Aggressive cholesterol lowering normalizes atherosclerosis regression in Jak2V617F mice”.
4 papers study it6 findingsUpdated
See all 4 papers on cholesterol lowering
At a glance
The findings reach mice, none yet in people. 1 lab in 1 country.
None of its findings points the other way.
- 1 lab in 1 country
- Funders: National Cancer Institute and 3 more
- 3 of 3 findings with company ties
- Humans1
- Animals1
What did studies of cholesterol lowering find?
5Studies of cholesterol lowering measured 5 outcomes; the most studied are inflammation (1 study), atherosclerosis progression (1) and atherosclerosis resolution (1).
Inflammation
downin mice1
1 study
Inflammation
downin mice1
Cholesterol lowering inhibits inflammation in mice (marked cholesterol lowering specifically in Jak2VF macrophages).
“reversal of increased proliferation, DNA damage and absent in melanoma 2 (AIM2) inflammasome activation specifically in Jak2VF macrophages”
Animalsmarked cholesterol lowering specifically in Jak2VF macrophages
Aggressive cholesterol lowering normalizes atherosclerosis regression in Jak2V617F mice
Journal of lipid research
Atherosclerosis progression
downin mice1
1 study
Atherosclerosis progression
downin mice1
Cholesterol lowering decreases atherosclerosis progression in mice with marked cholesterol lowering (to 100 mg/dl) in Jak2VF MPN and control mice.
“progression of lesions was halted in both Jak2VF MPN and control mice while macrophage burden was decreased and lesional collagen was increased”
Animalswith marked cholesterol lowering (to 100 mg/dl) in Jak2VF MPN and control mice
Aggressive cholesterol lowering normalizes atherosclerosis regression in Jak2V617F mice
Journal of lipid research
Atherosclerosis resolution
downin mice1
1 study
Atherosclerosis resolution
downin mice1
Cholesterol lowering decreases atherosclerosis resolution in mice.
“With moderate cholesterol lowering, there was impaired resolution of lesions in Jak2VF MPN mice compared to controls.”
Animalswith moderate cholesterol lowering (to 200-300 mg/dl) in Jak2VF MPN Ldlr-/- mice compared to controls
Aggressive cholesterol lowering normalizes atherosclerosis regression in Jak2V617F mice
Journal of lipid research
Cardiovascular disease
no changein humans1
1 study
Cardiovascular disease
no changein humans1
Cholesterol lowering showed no clear effect on cardiovascular disease in individuals with familial hypercholesterolemia.
“no controlled, randomized cholesterol-lowering trial restricted to those with FH has demonstrated a positive outcome”
Reviewin individuals with familial hypercholesterolemia
International journal of molecular sciences
Cardiovascular events
downin reviews1
1 study
Cardiovascular events
downin reviews1
Cholesterol lowering prevents cardiovascular events.
“lowering cholesterol level, especially low-density lipoprotein cholesterol level, protects cardiovascular system and prevents cardiovascular events effectively.”
Review
Signal transduction and targeted therapy
What is cholesterol lowering linked with?
1Studies link cholesterol lowering with 1 measure, most often cardiovascular disease (1 study).
Cardiovascular disease
downin silico1
1 study
Cardiovascular disease
downin silico1
Cholesterol lowering lowers the risk of cardiovascular disease in silico (to 0.8% in 2036 and 0.9% in 2050).
“Reducing total cholesterol (TC) by 0.05 mmol/L per year from 2026 would reduce incidence to 0.8% in 2036 and 0.9% in 2050.”
In silicoreducing TC by 0.05 mmol/L per year
AHA Scientific Sessions 2025 abstract
Funding
1 grant since 2020American Heart Association$954K