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Cgas-sting antagonist

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Cells1

Outcomes

1

Electrical activity

upin rat cells1

1 study

  1. Cgas-sting antagonist improves electrical activity in rat cells.

    “Finally, an antagonist of the cGAS-STING pathway was able to ameliorate the decrease in electrical activity early post-infection.”

    Cellsin SARS-CoV-2-infected primary rat cortical cultures early post-infectioncortex

    SARS-CoV-2-induced damage to rat cortical neuronal networks ex vivo is mediated by the pro-inflammatory activation of the cGAS-STING pathway

    Journal of neurovirology25 Oct 2025

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