Calibration

Calibration improves classification accuracy in silico (by 19 to 25 percentage points).

In silicoamong split-threshold panels in external validation

Equation Disagreement as a Zero-Cost Uncertainty Signal for LDL-C Classification: An Interpretable Regime-Aware Calibration Model Rescues Misclassification at Treatment Thresholds · The journal of applied laboratory medicine · 26 Sep 2026