Betaxolol

1. Betaxolol induces apoptosis in O. cuniculus.

   “Finally, clinical concentrations of betaxolol had a pro-apoptotic effect on rabbit corneal stromal cells in vivo.”

   Animalsclinical concentrationscornea

   Different concentrations of betaxolol switch cell fate between necroptosis, apoptosis, and senescence in human corneal stromal cells

   Chemico-biological interactions·5 Feb 2024

2. Betaxolol induces apoptosis in human cells.

   “moderate concentrations of betaxolol (0.07%-0.0175%) activated caspase-8 to trigger the exogenous apoptotic pathway.”

   Cellsmoderate concentrations (0.07%-0.0175%)cornea

   Different concentrations of betaxolol switch cell fate between necroptosis, apoptosis, and senescence in human corneal stromal cells

   Chemico-biological interactions·5 Feb 2024

More on Apoptosis

1. Betaxolol induces cellular senescence in human cells.

   “continuous treatment with low betaxolol concentrations (0.00875%) for three generations of HCSCs prevented apoptosis by promoting the expression of Bcl-xL and suppressing that of Bax. However, its toxic effects initiated cellular senescence”

   Cellscontinuous treatment with low concentrations (0.00875%) for three generationscornea

   Different concentrations of betaxolol switch cell fate between necroptosis, apoptosis, and senescence in human corneal stromal cells

   Chemico-biological interactions·5 Feb 2024

More on Cellular senescence

1. Betaxolol induces necroptosis in human cells.

   “At near-clinical concentrations (0.28% and 0.14%), betaxolol inhibited caspase-8 activity, activated receptor-interacting protein kinase (RIPK)1, RIPK3, and mixed-spectrum kinase-like domain (MLKL), and phosphorylated MLKL to induce necroptosis in HCSCs.”

   Cellsnear-clinical concentrations (0.28% and 0.14%)cornea

   Different concentrations of betaxolol switch cell fate between necroptosis, apoptosis, and senescence in human corneal stromal cells

   Chemico-biological interactions·5 Feb 2024