MLKL

5 papers7 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

1 lab in 1 country

Funders: National Institutes of Health and 4 more

Animals5

Effects

Inflammation

upin mice2

2 studies

MLKL increases inflammation in mice.
“inflammation, as measured by the levels of proinflammatory factors and mononuclear cell clusters, was increased in the hMlkl-KI mice.”
Animalshepatocyte MLKL overexpressionliver
Necroptosis induced by MLKL overexpression in liver triggers cellular senescence and leads to chronic inflammation and fibrosis
GeroScience24 Nov 2025
MLKL increases inflammation in mice.
“The increased necroptosis was associated with an induction of neuroinflammation as shown by an increase in transcript levels of inflammatory markers and increased Iba-1 expression in the cortex and hippocampus.”
Animalsin nMlkl-KI micecortex and hippocampus
Neuronal Necroptosis Drives Neuroinflammation and Cognitive Decline Independent of Neuronal Cell Death
Aging and disease16 Sep 2025