Base editing
Intervention2 papers1 finding
- Cells1
Outcomes
1Vascular disease characteristics
downin human cells1Very low certainty
1 study
Vascular disease characteristics
downin human cells1Very low certainty
Base editing decreases vascular disease characteristics in human cells.
CellsHGPS-associated mutationtrilayer tissue-engineered blood vessel
Support cells worsened disease features in lab-grown human vessels · Science advances · 7 Oct 2026
Funding
European Research Council€2mNational Institute on AgingUS$712.9kNational Institute of General Medical SciencesUS$583.7k3 grants since 2023
Advanced Delivery Platforms for Base Editing In Vivo
National Institute of General Medical SciencesUniv of Massachusetts Med Sch WorcesterUS$583.7k2023–2027
Base Editing of APOE4 for Alzheimer's Disease
National Institute on AgingUniversity of KentuckyUS$712.9k2026–2031
Advancing therapeutic base editing for vision loss
European Research CouncilInstitut fur Molekulare und Klinische Ophthalmologie Basel€2m2026–2031
Latest
2Support cells worsened disease features in lab-grown human vessels
Experiments with three-layer vessels built from human cells found that support cells increased several vascular disease features in a model of…Experiments with three-layer vessels built from human cells found that support cells increased several vascular disease features in a model of Hutchinson-Gilford progeria syndrome.