Aucubin

1. Aucubin inhibits cellular senescence in rats.

   “Moreover, Aucubin or Tanshinol treatment reduced IL-1β, TNF-α, P16, and P19 mRNA and protein expression, suppressed p65 phosphorylation, and decreased β-catenin protein contents within IDD samples.”

   Animalsin IDD ratsnucleus pulposus

   Aucubin and Tanshinol from Bu-Shen-Huo-Xue-Fang (BSHXF) improve intervertebral disc degeneration through affecting nucleus pulposus cell

   Journal of molecular histology·May 25, 2026

More on Cellular senescence

1. Aucubin decreases intervertebral disc degeneration in rats.

   “In IDD rats, Aucubin or Tanshinol treatment also remarkably relieved degenerative alterations.”

   Animalsin IDD rats

   Aucubin and Tanshinol from Bu-Shen-Huo-Xue-Fang (BSHXF) improve intervertebral disc degeneration through affecting nucleus pulposus cell

   Journal of molecular histology·May 25, 2026

More on Intervertebral disc degeneration

1. Aucubin improves physical function in worms.

   “increased locomotor activity, improved body wall muscle mitochondrial content, and alleviated oxidative damage in C. elegans”

   Model organisms

   Network Pharmacology Combined with Experimental Validation to Investigate the Effects and Mechanisms of Aucubin on Aging-Related Muscle Atrophy

   International journal of molecular sciences·Mar 14, 2025

1. Aucubin extends lifespan in worms.

   “AU treatment extended the average lifespan of Caenorhabditis elegans (C. elegans)”

   Model organisms

   Network Pharmacology Combined with Experimental Validation to Investigate the Effects and Mechanisms of Aucubin on Aging-Related Muscle Atrophy

   International journal of molecular sciences·Mar 14, 2025