Apoptotic vesicles
2 papers4 findings
- 1 lab in 1 country
- Funders: Guangdong Provincial Pearl River Talents Program and 4 more
- Animals2
Outcomes
4Aging phenotypes in the skeletal bones
downin mice1
1 study
Aging phenotypes in the skeletal bones
downin mice1
Apoptotic vesicles decrease aging phenotypes in the skeletal bones in mice.
“increased aging phenotypes in the skeletal bones, which can be rescued by the treatment with apoptosis inducer staurosporine (STS) and stem cell-derived apoptotic vesicles (apoVs)”
Animalsin aging mice and apoptosis-deficient MRL/lpr micebone
Journal of nanobiotechnologySep 6, 2024
PIEZO1
upin mice1
1 study
PIEZO1
upin mice1
Apoptotic vesicles increase PIEZO1 in mice.
“systemic infusion of apoVs was able to rescue Piezo1 expression and calcium influx”
Animalsmechanical unloading
Apoptotic vesicle-mediated senolytics requires mechanical loading
TheranosticsAug 6, 2024
Apoptotic resistance
downin mice1
1 study
Apoptotic resistance
downin mice1
Apoptotic vesicles decrease apoptotic resistance in mice.
“Systemic infusion of mesenchymal stem cell-derived apoVs can effectively rescue apoptotic resistance and eliminate senescent cells in mechanical unloading mice.”
Animalsmechanical unloading
Apoptotic vesicle-mediated senolytics requires mechanical loading
TheranosticsAug 6, 2024
Cellular senescence
downin mice1
1 study
Cellular senescence
downin mice1
Apoptotic vesicles decrease cellular senescence in mice.
“systemic infusion of apoVs was able to rescue Piezo1 expression and calcium influx, thereby, rescuing mechanical unloading-induced cellular apoptotic resistance, senescent cell accumulation.”
Animalsmechanical unloading
Apoptotic vesicle-mediated senolytics requires mechanical loading
TheranosticsAug 6, 2024