Apoe ε4 status
Apoe ε4 status has been studied in 5 papers since 2019: 5 observational studies in people; 3 in the past year. The newest paper, Jul 22, 2026: “Diffusion MRI Identifies a Prolonged Pre-WMH Phase in Cerebral Small Vessel Disease”.
5 papers study it6 findingsUpdated
See all 5 papers on apoe ε4 status
At a glance
The findings reach people, from one lab or study. 4 independent labs in 3 countries.
“Compared to WMH-/ε4-, adjusted hazard ratios (HRs) for dementia were: WMH-/ε4+, 1.5 (95% CI, 1.1-2.1)”
None of its findings points the other way.
- 4 independent labs in 3 countries
- Funders: Chinese Academy of Sciences Shanghai Branch and 8 more
- Humans5
What did studies of apoe ε4 status find?
5Studies of apoe ε4 status measured 5 outcomes; the most studied are total hippocampal volume (1 study), left fimbria volume (1) and fractional anisotropy and mean diffusivity (1).
Total hippocampal volume
no changein humans1
1 study
Total hippocampal volume
no changein humans1
Apoe ε4 status was not clearly linked with total hippocampal volume in humans (cognitively normal carriers; combined PEARL-Neuro and ADNI analysis).
“Combined analysis confirmed an overall left fimbria difference while total hippocampal volume remained preserved.”
Humanscognitively normal carriers; combined PEARL-Neuro and ADNI analysishippocampus
Behavioural brain research
Left fimbria volume
downin humans1
1 study
Left fimbria volume
downin humans1
Apoe ε4 status is linked with lower left fimbria volume in humans (cognitively normal carriers; discovery in PEARL-Neuro cohort) (uncorrected p < 0.001; surviving Bonferroni-corrected threshold of p < 0.0026).
“A selective reduction in left fimbria volume was initially discovered in the PEARL-Neuro cohort (uncorrected p < 0.001, surviving the Bonferroni-corrected threshold of p < 0.0026)”
Humanscognitively normal carriers; discovery in PEARL-Neuro cohorthippocampus
Behavioural brain research
Fractional anisotropy and mean diffusivity
no changein humans1
1 study
Fractional anisotropy and mean diffusivity
no changein humans1
Apoe ε4 status was not clearly linked with fractional anisotropy and mean diffusivity in humans.
“APOE ε4 status was not predictive of either measure.”
Humanswhite mattern = 49
Tract Specificity of Age Effects on Diffusion Tensor Imaging Measures of White Matter Health
Frontiers in aging neuroscience
Handgrip strength
no changein humans1
1 study
Handgrip strength
no changein humans1
Apoe ε4 status was not clearly linked with handgrip strength in humans (cross-sectional and prospective associations).
“No significant cross-sectional or prospective associations were found between ApoE ε4 status, lower-limb function and handgrip strength in our study.”
Humanscross-sectional and prospective associationsthree yearsn = 1,300
The Association of ApoE ε4 Status with Lower Limb Function and Handgrip Strength in Older Adults
The Journal of frailty & aging
Lower limb function
no changein humans1
1 study
Lower limb function
no changein humans1
Apoe ε4 status was not clearly linked with lower limb function in humans (cross-sectional and prospective associations).
“No significant cross-sectional or prospective associations were found between ApoE ε4 status, lower-limb function and handgrip strength in our study.”
Humanscross-sectional and prospective associationsthree yearsn = 1,300
The Association of ApoE ε4 Status with Lower Limb Function and Handgrip Strength in Older Adults
The Journal of frailty & aging
What is apoe ε4 status linked with?
1Studies link apoe ε4 status with 1 measure, most often dementia (1 study).
Dementia
upin humans1HR 1.5
1 study
Dementia
upin humans1HR 1.5
Apoe ε4 status is linked with a higher risk of dementia in WMH-negative individuals, ARIC cohort (HR 1.5 (95% CI 1.1–2.1) vs WMH-/ε4-).
“Compared to WMH-/ε4-, adjusted hazard ratios (HRs) for dementia were: WMH-/ε4+, 1.5 (95% CI, 1.1-2.1)”
Humansin WMH-negative individuals, ARIC cohort0 vs. ≥1 ε4 allelen = 1,736
Annals of neurology