AMMP9-LNP

1. AMMP9-LNP decreases senescence-associated secretory phenotype (SASP) in mice.

   “Mechanistically, MMP9 blockade dampened senescence-associated secretory phenotype, restored osteoblast-osteoclast balance, and lowered p21/MMP3.”

   Animalsin aged mice

   In vivo circRNA-engineered macrophages mediate localized MMP9 neutralization to rejuvenate aged bone

   Bioactive materials·22 May 2026

More on Senescence-associated secretory phenotype (SASP)

1. AMMP9-LNP decreases cartilage degeneration in mice.

   “mitigated cartilage degeneration”

   Animalsin aged mice

   In vivo circRNA-engineered macrophages mediate localized MMP9 neutralization to rejuvenate aged bone

   Bioactive materials·22 May 2026

1. AMMP9-LNP improves fracture repair in mice.

   “boosted osteogenesis, accelerated fracture repair, and mitigated cartilage degeneration”

   Animalsin aged mice

   In vivo circRNA-engineered macrophages mediate localized MMP9 neutralization to rejuvenate aged bone

   Bioactive materials·22 May 2026

1. AMMP9-LNP decreases stem cell senescence in mice.

   “In aged mice, systemic aMMP9-LNP reduced stem cell senescence, boosted osteogenesis, accelerated fracture repair, and mitigated cartilage degeneration.”

   Animalsin aged mice

   In vivo circRNA-engineered macrophages mediate localized MMP9 neutralization to rejuvenate aged bone

   Bioactive materials·22 May 2026