Alternative oxidase

1. Alternative oxidase inhibits AMPK signalling in mice.

   “Decreased ROS production in KO-AOX versus KO mice led to impaired AMPK/PGC-1α signaling”

   Animalsin skeletal muscle-specific COX15 knockout mice

   Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy

   Cell metabolism·16 Aug 2018

More on AMPK signalling

1. Alternative oxidase increases mitochondrial myopathies in mice.

   “double KO-AOX mutants had decreased lifespan and a substantial worsening of the myopathy compared with KO alone”

   Animalsin skeletal muscle-specific COX15 knockout mice

   Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy

   Cell metabolism·16 Aug 2018

More on Mitochondrial myopathies

1. Alternative oxidase shortens lifespan in mice.

   “double KO-AOX mutants had decreased lifespan and a substantial worsening of the myopathy compared with KO alone”

   Animalsin skeletal muscle-specific COX15 knockout mice

   Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy

   Cell metabolism·16 Aug 2018