Alcohol reduction

2 papers6 findings

One human study over 15 years links alcohol reduction to lower triglycerides, blood pressure and fasting glucose, but also lower HDL and higher LDL cholesterol, among participants consuming at least 20 g/day of ethanol at baseline.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: Japan Diabetes Society and 2 more
6 of 6 findings with company ties

Humans1

Outcomes

6

LDL cholesterol

upin humans1

1 study

Alcohol reduction increases LDL cholesterol in humans.
Humansbaseline ethanol intake ≥ 20 g/day15 years
Alcohol Reduction and 15-Year Cardiometabolic Changes in Glycemic, Lipid and Blood Pressure Profiles: A Target Trial Emulation Study
Diabetes, obesity & metabolism9 Sep 2026

More on LDL cholesterol

HDL cholesterol

downin humans1

1 study

Alcohol reduction decreases HDL cholesterol in humans.
Humansbaseline ethanol intake ≥ 20 g/day15 years
Alcohol Reduction and 15-Year Cardiometabolic Changes in Glycemic, Lipid and Blood Pressure Profiles: A Target Trial Emulation Study
Diabetes, obesity & metabolism9 Sep 2026

More on HDL cholesterol

Triglyceride

downin humans1

1 study

Alcohol reduction decreases triglyceride in humans (-20.4 mg/dL).
Humansbaseline ethanol intake ≥ 20 g/day15 years
Alcohol Reduction and 15-Year Cardiometabolic Changes in Glycemic, Lipid and Blood Pressure Profiles: A Target Trial Emulation Study
Diabetes, obesity & metabolism9 Sep 2026

More on Triglyceride

Diastolic blood pressure

downin humans1

1 study

Alcohol reduction decreases diastolic blood pressure in humans (-2.2 mmHg).
Humansbaseline ethanol intake ≥ 20 g/day15 years
Alcohol Reduction and 15-Year Cardiometabolic Changes in Glycemic, Lipid and Blood Pressure Profiles: A Target Trial Emulation Study
Diabetes, obesity & metabolism9 Sep 2026

Systolic blood pressure

downin humans1

1 study

Alcohol reduction decreases systolic blood pressure in humans (-3.4 mmHg).
Humansbaseline ethanol intake ≥ 20 g/day15 years
Alcohol Reduction and 15-Year Cardiometabolic Changes in Glycemic, Lipid and Blood Pressure Profiles: A Target Trial Emulation Study
Diabetes, obesity & metabolism9 Sep 2026

Fasting plasma glucose

downin humans1

1 study

Alcohol reduction decreases fasting plasma glucose in humans (-1.8 mg/dL).
Humansbaseline ethanol intake ≥ 20 g/day15 years
Alcohol Reduction and 15-Year Cardiometabolic Changes in Glycemic, Lipid and Blood Pressure Profiles: A Target Trial Emulation Study
Diabetes, obesity & metabolism9 Sep 2026

More on Fasting plasma glucose

Latest

2 in 12 months

Diabetes, Obesity & Metabolism10 Sep

Alcohol Reduction and 15-Year Cardiometabolic Changes in Glycemic, Lipid and Blood Pressure Profiles: A Target Trial Emulation Study

Cohort study of 266,699 peoplePopulations

World Health Organization, Geneva9 Aug

Risk reduction of cognitive decline and dementia: WHO guidelines, second edition

Systematic reviewIndustry & policy