Smoking + alcohol

Smoking + alcohol has been studied in 4 papers since 2026: 3 observational studies in people, 1 review; 4 in the past year. The newest story, Oct 4, 2026: “Low education linked to tripled premature mortality in India”.

Exposure

4 papers study it3 findingsUpdated

See all 4 papers on smoking + alcohol

At a glance

The findings reach people, from one lab or study. 3 independent labs in 3 countries.

“and together almost doubled male mortality (both versus neither, RR of 1.89, 95% CI 1.84-1.94)”
Combined impact of smoking, alcohol and social inequalities on premature mortality in urban IndiaNature health2026doi:10.1038/s44360-026-00148-4

None of its findings points the other way.

Humans: a single group. Cells, worms or flies and mice: nothing yet.
  • 3 independent labs in 3 countries
  • Funders: Amgen and others
  • 1 of 3 findings with company ties
  • Humans3

What did studies of smoking + alcohol find?

1

Studies of smoking + alcohol measured one outcome, total PSA.

Total PSA

upin humans1

1 study
  1. Smoking + alcohol is linked with higher total PSA in humans.

    “In the group that both smoked and consumed alcohol, tPSA, free PSA levels were significantly elevated.”

    Humansserummalesn = 160

    Assessment of Prostate Specific Antigen and Some Inflammatory Markers in Male Military Cigarette Smokers and Alcohol Users Attending Military Hospital Abuja, Nigeria

    International Journal of Biochemistry Research & Review

More on Total PSA

What is smoking + alcohol linked with?

2

Studies link smoking + alcohol with 2 measures: mortality and Parkinson's disease risk.

Mortality

upin humans1RR 1.89

1 study
  1. Smoking + alcohol is linked with a higher risk of mortality in humans (adjusted for education) (RR 1.89, 95% CI 1.84-1.94).

    “and together almost doubled male mortality (both versus neither, RR of 1.89, 95% CI 1.84-1.94)”

    Humansadjusted for educationmales

    Low education linked to tripled premature mortality in India

    Nature health

Parkinson's disease risk

downin humans1

1 study
  1. Smoking + alcohol is associated with Parkinson's disease risk in humans (Combined alcohol and smoking exposure) (Reported LRR = -0.37).

    “Combined alcohol and smoking exposure produced the greatest PD risk reduction (LRR = -0.37)”

    ReviewCombined alcohol and smoking exposure

    Impact of Alcohol Intake on Parkinson's Disease Risk and Progression: A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies

    Movement disorders : official journal of the Movement Disorder Society

More on Parkinson's disease risk

Latest

Dec 2025: 0Jan 2026: 1Feb 2026: 0Mar 2026: 1Apr 2026: 1May 2026: 0Jun 2026: 1Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 0Nov 2026: 04 papers in 12 months
Nature Health

Low education linked to tripled premature mortality in India

Among non-smoking non-drinkers, adults with no schooling had a mortality rate ratio of 2.76 in men and 2.93 in women compared to higher education.Among non-smoking non-drinkers, adults with no schooling had a mortality rate ratio of 2.76 in men and 2.93 in women compared to higher education.

Cohort study of 500,810 peoplePopulations