Adulthood adversity

4 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

3 independent labs in 3 countries

Funders: Medical Research Council and 1 more

Humans4

Outcomes

Grip strength

downin humans1

1 study

Adulthood adversity impairs grip strength in humans.
“Adulthood adversity was more strongly associated with certain ageing markers in males, particularly greater frailty and weaker grip strength.”
Humansmalesn = 153,557
Sex Differences in Associations Between Adversity and Biological Ageing
Aging cell1 Feb 2026

Frailty

upin humans1

1 study

Adulthood adversity increases frailty in humans.
“Adulthood adversity was more strongly associated with certain ageing markers in males, particularly greater frailty and weaker grip strength.”
Humansmalesn = 153,557
Sex Differences in Associations Between Adversity and Biological Ageing
Aging cell1 Feb 2026

Cognitive function

downin humans1

1 study

Adulthood adversity decreases cognitive function in humans (β = –0.014; 95% CI, –0.020 to –0.009; p < .001).
“adverse effect of adulthood adversity on cognitive decline was amplified among individuals with high childhood adversity (3‐way interaction: β = –0.014; 95% CI, –0.020 to –0.009; p < .001)”
Humansamong individuals with high childhood adversityn = 8,503
The associations of life course adversity on cognitive function and decline in the United States’ representative US Health and Retirement Study
AAIC 2025 abstract23 Dec 2025

Health deterioration

upin humans1

1 study

Adulthood adversity increases health deterioration in humans.
“childhood and adulthood adversities, including emotional abuse, community violence, and homelessness, significantly influence health deterioration and limit recovery.”
Humansn = 2,798
Patterns and transitions of physical, psychological, and behavioral health across adulthood: A latent transition analysis of the roles of childhood and adulthood adversities
Journal of affective disorders4 Sep 2025