Gzmk+ CD8 T cell differentiation
upin mice1
Adenosine induces gzmk+ CD8 T cell differentiation in mice.
“adenosine within aging tissues actively reprograms CD8+ T cells into a pro-aging Granzyme K + (Gzmk+) population.”
Animalsaging tissues
A feed-forward loop between niche adenosine and Gzmk⁺ CD8 T cells propagates systemic inflammaging
bioRxiv (Cold Spring Harbor Laboratory)20 Mar 2026Preprint
adenosine triphosphate generation
upin human cells1
Adenosine increases adenosine triphosphate generation in human cells.
“Repletion of adenosine, but not other nucleotides, restored adenosine triphosphate generation”
Cellsin cells with mtDNA mutations
Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations
Science (New York, N.Y.)4 Sep 2025
Studying sporadic ALS astrocyte models, researchers found TDP43 dysfunction impaired adenosine deaminase, disrupting purines and raising P16 levels while blunting…Studying sporadic ALS astrocyte models, researchers found TDP43 dysfunction impaired adenosine deaminase, disrupting purines and raising P16 levels while blunting 53BP1-mediated repair.