AC2-26

1. AC2-26 decreases MMP13 in human cells.

   “TNF-α caused elevations in the mRNA and protein levels of MMP-13 and ADAMTS-4, which were reduced by Ac2-26 in a dose-dependent fashion.”

   Cellsin TNF-α-treated CHON-001 chondrocytes

   The Annexin A1 Protein Mimetic Peptide Ac2-26 prevents cellular senescence of CHON-001 chondrocytes against tumor necrosis factor-α via the Nrf2/NF-κB pathway

   Biotechnology and applied biochemistry·Nov 22, 2024

More on MMP13

1. AC2-26 decreases oxidative stress and ROS signalling in human cells.

   “Ac2-26 alleviated OS by reducing mitochondrial reactive oxygen species levels and promoting the activation of NF-E2-related factor 2 (Nrf2) in TNF-α-challenged CHON-001 chondrocytes.”

   Cellsin TNF-α-treated CHON-001 chondrocytes

   The Annexin A1 Protein Mimetic Peptide Ac2-26 prevents cellular senescence of CHON-001 chondrocytes against tumor necrosis factor-α via the Nrf2/NF-κB pathway

   Biotechnology and applied biochemistry·Nov 22, 2024

More on Oxidative stress and ROS signalling

1. AC2-26 increases telomerase activity in human cells.

   “Ac2-26 mitigated the reduction of telomerase activity and the exacerbation of cellular senescence induced by TNF-α in CHON-001 chondrocytes.”

   Cellsin TNF-α-treated CHON-001 chondrocytes

   The Annexin A1 Protein Mimetic Peptide Ac2-26 prevents cellular senescence of CHON-001 chondrocytes against tumor necrosis factor-α via the Nrf2/NF-κB pathway

   Biotechnology and applied biochemistry·Nov 22, 2024

More on Telomerase activity

1. AC2-26 decreases cellular senescence in human cells.

   “Ac2-26 mitigated the reduction of telomerase activity and the exacerbation of cellular senescence induced by TNF-α in CHON-001 chondrocytes.”

   Cellsin TNF-α-treated CHON-001 chondrocytes

   The Annexin A1 Protein Mimetic Peptide Ac2-26 prevents cellular senescence of CHON-001 chondrocytes against tumor necrosis factor-α via the Nrf2/NF-κB pathway

   Biotechnology and applied biochemistry·Nov 22, 2024

More on Cellular senescence

1. AC2-26 decreases vascular remodeling in mice.

   “Conversely, Ac2-26 (a mimetic peptide of ANXA1) supplementation reverses this phenomenon.”

   AnimalsANXA1-deficient mice

   Loss of Endothelial Annexin A1 Aggravates Inflammation-Induched Vascular Aging

   Advanced science (Weinheim, Baden-Wurttemberg, Germany)·Feb 15, 2024