AAV9-SERPINA3K gene therapy

1. AAV9-SERPINA3K gene therapy decreases cardiac fibrosis in mice.

   “AAV9-mediated cardiomyocyte-specific overexpression in middle-aged mice, which attenuated the cGAS-STING-PERK axis and mitigated age-related fibrosis.”

   Animalsage-related fibrosisAAV9-mediated cardiomyocyte-specific overexpressionheart

   Multi-region proteomic mapping identifies FTL1 and SERPINA3K as protective factors in cardiac aging

   Cell death & disease·23 May 2026

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