AAV-LAV-BPIFB4

1. AAV-LAV-BPIFB4 increases NAD+ in mice.

   “the reduction of senescence-associated inflammation ensured sustained NAD+ levels in the plasma of AAV-LAV-BPIFB4 old mice”

   Animalsaged miceplasma

   Transfer of the longevity-associated variant of BPIFB4 gene rejuvenates immune system and vasculature by a reduction of CD38⁺ macrophages and NAD⁺ decline

   Cell death & disease·27 Jan 2022

More on NAD+

1. AAV-LAV-BPIFB4 decreases senescence-associated beta-galactosidase in mice.

   “associated with a significant reduction in SA-beta Gal-positive area of aorta from AAV-LAV treated mice.”

   Animalsaged miceaorta

   Transfer of the longevity-associated variant of BPIFB4 gene rejuvenates immune system and vasculature by a reduction of CD38⁺ macrophages and NAD⁺ decline

   Cell death & disease·27 Jan 2022

More on Senescence-associated beta-galactosidase

1. AAV-LAV-BPIFB4 decreases immunosenescent cells in mice.

   “Notably, AAV-LAV-BPIFB4 gene transfer in aged mice reduced the pool of peripheral immunosenescent cells”

   Animalsaged mice

   Transfer of the longevity-associated variant of BPIFB4 gene rejuvenates immune system and vasculature by a reduction of CD38⁺ macrophages and NAD⁺ decline

   Cell death & disease·27 Jan 2022

More on Immunosenescent cells