8-aminoguanine

1. 8-aminoguanine improves electroretinogram responses in rats.

   “8-AG significantly preserves retinal structure and function, as evidenced by increased retinal thickness, enhanced photoreceptor integrity, and improved electroretinogram responses.”

   Animalsdrinking waterretina8 weeks

   Oral 8-aminoguanine against age-related retinal degeneration

   Communications biology·26 May 2025

2. 8-aminoguanine improves electroretinogram responses in rats.

   “This was evidenced by increased retinal thickness, improved photoreceptor integrity, and enhanced electroretinogram responses.”

   Animalsaged Fischer 344 ratsdrinking waterretina5 mg/kg body weight8 weeks

   Oral 8-aminoguanine against age-related retinal degeneration

   Research square·6 May 2024Preprint

1. 8-aminoguanine decreases inflammation in rats.

   “8-AG also mitigates retinal inflammation at transcriptional and cytokine levels.”

   Animalsretina

   Oral 8-aminoguanine against age-related retinal degeneration

   Communications biology·26 May 2025

More on Inflammation

1. 8-aminoguanine decreases oxidative stress and ROS signalling in rats.

   “8-AG reduces apoptosis, oxidative damage, and microglial/macrophage activation in aging retinae.”

   Animalsdrinking waterretina8 weeks

   Oral 8-aminoguanine against age-related retinal degeneration

   Communications biology·26 May 2025

More on Oxidative stress and ROS signalling

1. 8-aminoguanine decreases apoptosis in rats.

   “8-AG reduces apoptosis, oxidative damage, and microglial/macrophage activation in aging retinae.”

   Animalsdrinking waterretina8 weeks

   Oral 8-aminoguanine against age-related retinal degeneration

   Communications biology·26 May 2025

More on Apoptosis

1. 8-aminoguanine decreases active microglia/macrophages in mice.

   “Moreover, 8-AG showed temporary protective effects in the Rho P23H/+ mouse model of retinitis pigmentosa, reducing active microglia/macrophages.”

   AnimalsRho P23H/+ mouse model of retinitis pigmentosaretina

   Oral 8-aminoguanine against age-related retinal degeneration

   Research square·6 May 2024Preprint

More on Active microglia/macrophages

1. 8-aminoguanine decreases age-induced retinal purine metabolome alterations in rats.

   “Age-induced alterations in the retinal purine metabolome, characterized by elevated levels of inosine, hypoxanthine, and xanthine, were partially mitigated by 8-AG.”

   Animalsaged Fischer 344 ratsretina

   Oral 8-aminoguanine against age-related retinal degeneration

   Research square·6 May 2024Preprint

1. 8-aminoguanine decreases microglial/macrophage activation in rats.

   “8-AG effectively reduced apoptosis, oxidative damage, and microglial/macrophage activation associated with aging retinae.”

   Animalsaged Fischer 344 ratsretina

   Oral 8-aminoguanine against age-related retinal degeneration

   Research square·6 May 2024Preprint

1. 8-aminoguanine decreases oxidative damage in rats.

   “8-AG effectively reduced apoptosis, oxidative damage, and microglial/macrophage activation associated with aging retinae.”

   Animalsaged Fischer 344 ratsretina

   Oral 8-aminoguanine against age-related retinal degeneration

   Research square·6 May 2024Preprint

1. 8-aminoguanine increases retinal thickness in rats.

   “This was evidenced by increased retinal thickness, improved photoreceptor integrity, and enhanced electroretinogram responses.”

   Animalsaged Fischer 344 ratsdrinking waterretina5 mg/kg body weight8 weeks

   Oral 8-aminoguanine against age-related retinal degeneration

   Research square·6 May 2024Preprint

1. 8-aminoguanine decreases hypertension in rats.

   “Chronic treatment with 8-aminoguanine attenuates hypertension in deoxycorticosterone/salt rats”

   Reviewdeoxycorticosterone/salt

   8-Aminopurines in the Cardiovascular and Renal Systems and Beyond

   Hypertension (Dallas, Tex. : 1979)·28 Jul 2023

More on Hypertension