AgingResearch.NewsJoin free

7-chloro-4-(phenylselanyl) quinoline

Intervention

1 paper3 findings

PubChemChEBIMeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico and 5 more
  • Animals1

Outcomes

3

Oxidative stress and ROS signalling

downin rats1

1 study

  1. 7-chloro-4-(phenylselanyl) quinoline decreases oxidative stress and ROS signalling in rats.

    “mitigating oxidative stress, neuroinflammation, and related apoptotic pathways in aged rats”

    Animalsoxaliplatin-treated

    Aging as a critical factor in chronic oxaliplatin-induced neuropathy: Protective effects of 7-chloro-4-(phenylselanyl) quinoline through modulation of NF-κB and Drp1 expression, and platinum distribution

    Biochemical pharmacology21 Aug 2025

More on Oxidative stress and ROS signalling

DNM1L

downin rats1

1 study

  1. 7-chloro-4-(phenylselanyl) quinoline decreases DNM1L in rats.

    “reducing nuclear factor kappa B (NF-κB) and Drp1 expression levels”

    Animalsoxaliplatin-treated

    Aging as a critical factor in chronic oxaliplatin-induced neuropathy: Protective effects of 7-chloro-4-(phenylselanyl) quinoline through modulation of NF-κB and Drp1 expression, and platinum distribution

    Biochemical pharmacology21 Aug 2025

More on DNM1L

Neuropathic symptoms

upin rats1

1 study

  1. 7-chloro-4-(phenylselanyl) quinoline improves neuropathic symptoms in rats.

    “Our study demonstrates the potential of 4-PSQ in alleviating neuropathic symptoms”

    Animalsoxaliplatin-induced neuropathy

    Aging as a critical factor in chronic oxaliplatin-induced neuropathy: Protective effects of 7-chloro-4-(phenylselanyl) quinoline through modulation of NF-κB and Drp1 expression, and platinum distribution

    Biochemical pharmacology21 Aug 2025

Latest

Related