6ppd

1. 6ppd induces cellular senescence in mice (≥12 mg/kg/d).

   “exposure to high doses of 6PPD causes placental senescence (≥12 mg/kg/d) to induce mouse miscarriage (≥36 mg/kg/d).”

   Animalsplacenta≥12 mg/kg/d

   Exposure to high doses of tyre antioxidant 6PPD causes senescence to induce unexplained miscarriage by suppressing BAZ1B-mediated ubiquitination degradation of P21

   EBioMedicine·1 Jun 2026

More on Cellular senescence

1. 6ppd induces unexplained miscarriage in mice (≥36 mg/kg/d).

   “exposure to high doses of 6PPD causes placental senescence (≥12 mg/kg/d) to induce mouse miscarriage (≥36 mg/kg/d).”

   Animals≥36 mg/kg/d

   Exposure to high doses of tyre antioxidant 6PPD causes senescence to induce unexplained miscarriage by suppressing BAZ1B-mediated ubiquitination degradation of P21

   EBioMedicine·1 Jun 2026

More on Unexplained miscarriage

1. 6ppd is associated with unexplained miscarriage in humans.

   “Higher urinary 6PPD levels are closely associated with villous tissue senescence and miscarriage (n = 50).”

   Humansvillous tissuen = 50

   Exposure to high doses of tyre antioxidant 6PPD causes senescence to induce unexplained miscarriage by suppressing BAZ1B-mediated ubiquitination degradation of P21

   EBioMedicine·1 Jun 2026

More on Unexplained miscarriage