Unexplained miscarriage

1 paper3 findings

Humans1

Interventions

1

6ppd

upin mice1

1 study

6ppd induces unexplained miscarriage in mice (≥36 mg/kg/d).
“exposure to high doses of 6PPD causes placental senescence (≥12 mg/kg/d) to induce mouse miscarriage (≥36 mg/kg/d).”
Animals≥36 mg/kg/d
Exposure to high doses of tyre antioxidant 6PPD causes senescence to induce unexplained miscarriage by suppressing BAZ1B-mediated ubiquitination degradation of P21
EBioMedicine1 Jun 2026

Upstream

1

BAZ1B

downin mice1

1 study

BAZ1B protects against unexplained miscarriage in mice.
“Therapeutic down-regulation of p21, supplement with murine Baz1b, or direct suppression of senescence could effectively reduce placental senescence and suppress mouse miscarriage in the 6PPD-exposed mouse models.”
Animalsin 6PPD-exposed mouse models
Exposure to high doses of tyre antioxidant 6PPD causes senescence to induce unexplained miscarriage by suppressing BAZ1B-mediated ubiquitination degradation of P21
EBioMedicine1 Jun 2026

Associations

1

6ppd

upin humans1

1 study

6ppd is associated with unexplained miscarriage in humans.
“Higher urinary 6PPD levels are closely associated with villous tissue senescence and miscarriage (n = 50).”
Humansvillous tissuen = 50
Exposure to high doses of tyre antioxidant 6PPD causes senescence to induce unexplained miscarriage by suppressing BAZ1B-mediated ubiquitination degradation of P21
EBioMedicine1 Jun 2026

Latest

1 in 12 months

EBioMedicine1 Jun

Exposure to high doses of tyre antioxidant 6PPD causes senescence to induce unexplained miscarriage by suppressing BAZ1B-mediated ubiquitination degradation of P21

Case-control study of 50 peopleCellular senescence