Hepatotoxicity
Disease1 paper1 finding
- Animals1
Interventions
1GFD-CD3 bite
upin animals1
1 study
GFD-CD3 bite
upin animals1
GFD-CD3 bite induces hepatotoxicity.
“high-dose GFD-CD3 predominantly induced hepatotoxicity through T cell-mediated attack on hepatic endothelial cells.”
Animalshigh-dosehepatic endothelial cellshigh-dose
Bispecific T cell engager eliminates senescent cells in mice and nonhuman primates · Aging cell · 29 Sep 2026
Latest
1AnimalsCellular senescence
Bispecific T cell engager eliminates senescent cells in mice and nonhuman primates
Monitored by serum transaminase levels, low doses of the drug alleviated age-related pathologies without causing the hepatotoxicity seen at higher doses.