2-methoxyestradiol
- 2 independent labs in 1 country
- 1 finding against
- Funders: Beijing Municipal Natural Science Foundation and 3 more
- Animals2
Outcomes
4Bone-vessel metabolism
downin mice1upin mice1
1 study
Bone-vessel metabolism
downin mice1upin mice1
2-methoxyestradiol impairs bone-vessel metabolism in mice.
“while damaged that of young mice”
Animalsyoung micegavage4-w
A dual role of HIF1α in regulating osteogenesis-angiogenesis coupling
Stem cell research & therapyFeb 5, 2022
2-methoxyestradiol improves bone-vessel metabolism in mice.
“2-methoxyestradiol improved bone-vessel metabolism of aged mice”
Animalsaged micegavage4-w
A dual role of HIF1α in regulating osteogenesis-angiogenesis coupling
Stem cell research & therapyFeb 5, 2022
Apoptosis
upin mouse cells1
1 study
Apoptosis
upin mouse cells1
2-methoxyestradiol induces apoptosis in mouse cells.
“as well as accelerated apoptosis progression.”
Cellsin vitro
Adverse effects of 2-Methoxyestradiol on mouse oocytes during reproductive aging
Chemico-biological interactionsNov 19, 2022
Oxidative stress and ROS signaling
upin mouse cells1
1 study
Oxidative stress and ROS signaling
upin mouse cells1
2-methoxyestradiol induces oxidative stress and ROS signaling in mouse cells.
“2-ME2 exposure induced excessive production of reactive oxygen species (ROS) and malondialdehyde”
Cellsin vitro
Adverse effects of 2-Methoxyestradiol on mouse oocytes during reproductive aging
Chemico-biological interactionsNov 19, 2022
Oocyte meiotic maturation
downin mice1
1 study
Oocyte meiotic maturation
downin mice1
2-methoxyestradiol impairs oocyte meiotic maturation in mice.
“2-ME2 exposure impairs oocyte meiotic maturation through inducing mitochondrial imbalance, oxidative stress and apoptosis.”
Animalsin vitro and in vivo (intraperitoneal injection)
Adverse effects of 2-Methoxyestradiol on mouse oocytes during reproductive aging
Chemico-biological interactionsNov 19, 2022