2′-deoxycytidine-based lead compound

1. 2′-deoxycytidine-based lead compound extends lifespan in worms.

   “Importantly, the conjugated compound significantly extended C. elegans lifespan at lower concentrations compared with the unconjugated analogue.”

   Model organismsEffective at lower concentrations compared with the unconjugated analogueCy5 conjugate

   Cyanine dye conjugates of a 2’-deoxycytidine-based auto- and mitophagy activator extend Caenorhabditis elegan s lifespan

   bioRxiv (Cold Spring Harbor Laboratory)·25 Jan 2026Preprint

1. 2′-deoxycytidine-based lead compound increases mitophagy in worm cells.

   “Conjugation of the lead compound with the mitochondria-targeting Cy5 dye further potentiated mitophagy induction”

   CellsCompared with the unconjugated lead compoundCy5 conjugate

   Cyanine dye conjugates of a 2’-deoxycytidine-based auto- and mitophagy activator extend Caenorhabditis elegan s lifespan

   bioRxiv (Cold Spring Harbor Laboratory)·25 Jan 2026Preprint

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