2,4-dinitrophenol
- 2 independent labs in 1 country
- Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico and 4 more
- Animals5
- In silico1
Mouse lifespan
NIA ITPOutcomes
8Lifespan
upin mice2upin rats1
3 studies
Lifespan
upin mice2upin rats1
2,4-dinitrophenol extends lifespan in mice.
“The weak uncoupler dinitrophenol (DNP) prolongs the life span of mice”
Reviewin mice
Healthy Aging: Antioxidants, Uncouplers and/or Telomerase?
Molekuliarnaia biologiia1 Jan 2020
2,4-dinitrophenol extends lifespan in rats.
“and also by increase of their mean lifespan”
Animalslivermales
Advances in gerontology = Uspekhi gerontologii1 Jan 2010
2,4-dinitrophenol extends lifespan in mice.
“2,4-dinitrophenol-treated animals also presented enhanced longevity.”
Animalslow doses
Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity
Aging cell10 Jul 2008
Oxidative stress and ROS signalling
downin mice1downin rats1
2 studies
Oxidative stress and ROS signalling
downin mice1downin rats1
2,4-dinitrophenol decreases oxidative stress and ROS signalling in rats.
“decrease of the rate of reactive oxygen species formation in microsomal redox-chain”
Animalslivermales
Advances in gerontology = Uspekhi gerontologii1 Jan 2010
2,4-dinitrophenol decreases oxidative stress and ROS signalling in mice.
“decrease of reactive oxygen species levels and tissue DNA and protein oxidation”
Animalslow doses
Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity
Aging cell10 Jul 2008
traumatic brain damage
downin mice1
1 study
traumatic brain damage
downin mice1
2,4-dinitrophenol decreases traumatic brain damage in mice.
“reduces traumatic brain damage, and inhibits the development of a number of neurodegenerative diseases.”
Reviewin mice
Healthy Aging: Antioxidants, Uncouplers and/or Telomerase?
Molekuliarnaia biologiia1 Jan 2020
NOS3
upin mice1
1 study
NOS3
upin mice1
2,4-dinitrophenol activates NOS3 in mice.
“In addition, eNOS and Akt phosphorylation in skeletal muscle and visceral adipose tissue was activated in fasting CR and DNP animals.”
Animalsfasting
PloS one31 Mar 2011
Mitochondrial biogenesis (PGC-1α)
upin mice1
1 study
Mitochondrial biogenesis (PGC-1α)
upin mice1
2,4-dinitrophenol increases mitochondrial biogenesis (PGC-1α) in mice.
“DNP and CR increase citrate synthase activity, PGC-1α, cytochrome c oxidase and mitofusin-2 expression, as well as fasting plasma levels of NO• products.”
Animalsfasting
PloS one31 Mar 2011
Protein carbonyls
downin rats1
1 study
Protein carbonyls
downin rats1
2,4-dinitrophenol decreases protein carbonyls in rats.
“decline in lipid hydroperoxides and protein carbonils levels in blood serum and liver microsomes”
Animalsmales
Advances in gerontology = Uspekhi gerontologii1 Jan 2010
Lipid hydroperoxides
downin rats1
1 study
Lipid hydroperoxides
downin rats1
2,4-dinitrophenol decreases lipid hydroperoxides in rats.
“decline in lipid hydroperoxides and protein carbonils levels in blood serum and liver microsomes”
Animalsmales
Advances in gerontology = Uspekhi gerontologii1 Jan 2010
Body weight
downin mice1
1 study
Body weight
downin mice1
2,4-dinitrophenol decreases body weight in mice.
“reduced body weight.”
Animalslow doses
Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity
Aging cell10 Jul 2008