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16-hydroxyestriol

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Against: findings that point the other way from most findings on the same outcome.

  • 1 lab in 1 country
  • 1 finding against
  • Funders: National Institute on Aging and 1 more
  • Animals1

Outcomes

1

Lifespan

downin mice1upin mice1−7%

1 study

  1. 16-hydroxyestriol shortens lifespan in mice (-7%).

    “but led to a significant (7%) decline in female lifespan.”

    Animalsfemales

    Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin

    GeroScience16 May 2024

  2. 16-hydroxyestriol extends lifespan in mice (+15%, p = 0.0001).

    “OH_Est produced a 15% increase (p = 0.0001) in median lifespan in males”

    Animalsmales

    Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin

    GeroScience16 May 2024

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