AgingResearch.NewsJoin free

2,3,5,4'-tetrahydroxystilbene-2-o-beta-d-glucoside

Intervention

4 papers study it11 findings

PubChemChEBI

Across all fields, 4 papers: none in people yet, 3 in animals, 1 review

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 4 independent labs in 2 countries
  • Funders: National Natural Science Foundation of China and 8 more
  • Animals2
  • Model organisms1

Outcomes

10

Lifespan

upin reviews1upin worms1+16% mean lifespan

2 studies

  1. 2,3,5,4'-tetrahydroxystilbene-2-o-beta-d-glucoside extends lifespan.

    “TSG exhibits comprehensive anti-aging effects, including lifespan extension”

    Review

    2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) from Polygonum multiflorum Thunb.: A Systematic Review on Anti-Aging

    International journal of molecular sciences

  2. 2,3,5,4'-tetrahydroxystilbene-2-o-beta-d-glucoside extends lifespan in worms (+16.48% mean lifespan).

    “200 μM TSG significantly extended the mean lifespan of Caenorhabditis elegans by 16.48%”

    Model organisms200 μM

    TSG Extends the Longevity of Caenorhabditis elegans by Targeting the DAF-16/SKN-1/SIR-2.1-Mediated Mitochondrial Quality Control Process

    Antioxidants (Basel, Switzerland)

Atherosclerosis

downin reviews1

1 study

  1. 2,3,5,4'-tetrahydroxystilbene-2-o-beta-d-glucoside decreases atherosclerosis.

    “cardiovascular protection (e.g., reducing atherosclerosis and hypertension)”

    Review

    2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) from Polygonum multiflorum Thunb.: A Systematic Review on Anti-Aging

    International journal of molecular sciences

More on Atherosclerosis

Alzheimer's disease

downin reviews1

1 study

  1. 2,3,5,4'-tetrahydroxystilbene-2-o-beta-d-glucoside decreases Alzheimer's disease.

    “neuroprotection (e.g., ameliorating Alzheimer's and Parkinson's diseases)”

    Review

    2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) from Polygonum multiflorum Thunb.: A Systematic Review on Anti-Aging

    International journal of molecular sciences

More on Alzheimer's disease

Healthspan

upin worms1

1 study

  1. 2,3,5,4'-tetrahydroxystilbene-2-o-beta-d-glucoside improves healthspan in worms.

    “improved health status by delaying age-associated physiological decline in worms”

    Model organisms200 μM

    TSG Extends the Longevity of Caenorhabditis elegans by Targeting the DAF-16/SKN-1/SIR-2.1-Mediated Mitochondrial Quality Control Process

    Antioxidants (Basel, Switzerland)

Cell proliferation

upin mouse cells1

1 study

  1. 2,3,5,4'-tetrahydroxystilbene-2-o-beta-d-glucoside increases cell proliferation in mouse cells.

    “Next results displayed that TSG promoted cell proliferation as well as ATP level in mice primary hepatocytes, which were abolished when PPARα was suppressed.”

    Cellsprimary hepatocytes

    2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside promotes liver regeneration after partial hepatectomy in mice: The potential involvement of PPARα-mediated fatty acid metabolism

    Journal of ethnopharmacology

Triglyceride

downin mice1

1 study

  1. 2,3,5,4'-tetrahydroxystilbene-2-o-beta-d-glucoside decreases triglyceride in mice.

    “TSG lowered hepatic triglyceride (TG) and non-esterified fatty acid (NEFA) amounts and increased hepatic adenosine triphosphate (ATP) level in mice after PHx.”

    Animalsafter partial hepatectomyliver

    2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside promotes liver regeneration after partial hepatectomy in mice: The potential involvement of PPARα-mediated fatty acid metabolism

    Journal of ethnopharmacology

More on Triglyceride

Liver regeneration

upin mice1

1 study

  1. 2,3,5,4'-tetrahydroxystilbene-2-o-beta-d-glucoside improves liver regeneration in mice.

    “TSG (20 mg/kg) promoted LR in mice after PHx.”

    Animalsafter partial hepatectomyliver20 mg/kg

    2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside promotes liver regeneration after partial hepatectomy in mice: The potential involvement of PPARα-mediated fatty acid metabolism

    Journal of ethnopharmacology

Mitochondrial biogenesis (PGC-1α)

upin mice1

1 study

  1. 2,3,5,4'-tetrahydroxystilbene-2-o-beta-d-glucoside increases mitochondrial biogenesis (PGC-1α) in mice.

    “THSG increased the expression of pgc1α and atp6, mitochondrial biogenesis-related genes, and their protein expression.”

    Animalsin young and aged micegavageovary10 mg/kg twice weeklyfemales

    2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside improves female ovarian aging

    Frontiers in cell and developmental biology

More on Mitochondrial biogenesis (PGC-1α)

Ovary quality

upin mice1

1 study

  1. 2,3,5,4'-tetrahydroxystilbene-2-o-beta-d-glucoside improves ovary quality in mice.

    “THSG administration increased the quality of ovaries in young mice becoming aged.”

    Animalsduring aginggavageovary10 mg/kg twice weeklyfemales

    2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside improves female ovarian aging

    Frontiers in cell and developmental biology

Oocyte number

upin mice1

1 study

  1. 2,3,5,4'-tetrahydroxystilbene-2-o-beta-d-glucoside increases oocyte number in mice.

    “The number of oocytes in the THSG-fed group was higher than in the untreated control group.”

    Animalsduring aginggavageovary10 mg/kg twice weeklyfemales

    2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside improves female ovarian aging

    Frontiers in cell and developmental biology

Latest

Related