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16:8 intermittent fasting

Intervention

1 paper5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Human trial1

Outcomes

5

HOMA-IR

downin humans1

1 study

  1. 16:8 intermittent fasting decreases HOMA-IR in humans.

    “early feeding window (8h to 16h) in the IF group was associated with greater reductions in weight, fat mass, waist circumference and HOMA insulin resistance index (p=0.001 for all)”

    Human trialcompared to 12h to 20h window3 monthsfemalesn = 45

    Comparative Effects of 16:8 Intermittent Fasting and Continuous Caloric Restriction on Metabolic Syndrome Components in obese Women: A Non-randomized Controlled Clinical Trial

    La Tunisie medicale1 Aug 2025

More on HOMA-IR

HDL cholesterol

upin humans1

1 study

  1. 16:8 intermittent fasting increases HDL cholesterol in humans.

    “increasing HDL-cholesterol (p=0.01).”

    Human trialcompared with continuous caloric restriction3 monthsfemales

    Comparative Effects of 16:8 Intermittent Fasting and Continuous Caloric Restriction on Metabolic Syndrome Components in obese Women: A Non-randomized Controlled Clinical Trial

    La Tunisie medicale1 Aug 2025

More on HDL cholesterol

Glucose

downin humans1

1 study

  1. 16:8 intermittent fasting decreases glucose in humans.

    “IF was more effective than CCR in reducing blood glucose (p=0.04) and triglyceride levels (p=0.02) and increasing HDL-cholesterol (p=0.01).”

    Human trialcompared with continuous caloric restriction3 monthsfemales

    Comparative Effects of 16:8 Intermittent Fasting and Continuous Caloric Restriction on Metabolic Syndrome Components in obese Women: A Non-randomized Controlled Clinical Trial

    La Tunisie medicale1 Aug 2025

More on Glucose

Waist circumference

downin humans1

1 study

  1. 16:8 intermittent fasting decreases waist circumference in humans.

    “Fat mass and waist circumference reductions were more pronounced in the IF group (p=0.04 and p=0.0001, respectively).”

    Human trialcompared with continuous caloric restriction3 monthsfemales

    Comparative Effects of 16:8 Intermittent Fasting and Continuous Caloric Restriction on Metabolic Syndrome Components in obese Women: A Non-randomized Controlled Clinical Trial

    La Tunisie medicale1 Aug 2025

Body weight

downin humans1

1 study

  1. 16:8 intermittent fasting decreases body weight in humans (-7.38 ± 4.1 kg vs. -5.41 ± 3.84 kg).

    “the IF group showing greater weight change (-7.38 ± 4.1 kg vs. -5.41 ± 3.84 kg, p=0.03).”

    Human trialcompared with continuous caloric restriction3 monthsfemales

    Comparative Effects of 16:8 Intermittent Fasting and Continuous Caloric Restriction on Metabolic Syndrome Components in obese Women: A Non-randomized Controlled Clinical Trial

    La Tunisie medicale1 Aug 2025

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