ZNF865

1 paper5 findings

HGNC 38705 NCBI Gene 100507290 Taxon 9606

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

1 lab in 1 country

Cells1

Effects

Intervertebral disc degeneration

downin animals1

1 study

ZNF865 protects against intervertebral disc degeneration.
Animalsshown by CRISPRi of ZNF865 in vivo; species not specified for this experimentintervertebral disc
Restoring a protein reduced DNA damage in human disc cells
Aging cell1 Oct 2026

More on Intervertebral disc degeneration

Extracellular matrix anabolism

upin human cells1

1 study

ZNF865 increases extracellular matrix anabolism in human cells.
CellsZNF865 restoration in degenerative NP cellsnucleus pulposus
Restoring a protein reduced DNA damage in human disc cells
Aging cell1 Oct 2026

DNA damage

downin human cells1

1 study

ZNF865 decreases DNA damage in human cells.
CellsZNF865 restoration in degenerative NP cellsnucleus pulposus
Restoring a protein reduced DNA damage in human disc cells
Aging cell1 Oct 2026

SASP expression

downin human cells1

1 study

ZNF865 decreases SASP expression in human cells.
CellsZNF865 restoration in degenerative NP cellsnucleus pulposus
Restoring a protein reduced DNA damage in human disc cells
Aging cell1 Oct 2026

Latest

1 in 12 months

Aging Cell2 h

Restoring a protein reduced DNA damage in human disc cells

Experiments that altered gene activity in human spinal disc cells found that restoring the protein also reduced senescence, a state in which cells stop dividing.Experiments that altered gene activity in human spinal disc cells found that restoring the protein also reduced senescence, a state in which cells stop dividing.

Experiments in human cellsDNA damage response

Paper

ZNF865

Effects

Latest

Restoring a protein reduced DNA damage in human disc cells

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