VAPB

1. VAPB shortens lifespan in flies.

   “VAPB P58S flies show progressive age-dependent motor deficits and a shortened lifespan”

   Model organismsVAPB P58S model

   Fos regulates age-dependent neuroinflammation in VAPB ALS

   bioRxiv (Cold Spring Harbor Laboratory)·3 Mar 2026Preprint

1. VAPB is associated with triacylglycerols in mice.

   “Vapb knock-out mice exhibit abnormal muscular triacylglycerol levels”

   Animalsshown by knockoutstriated muscle

   VAPB/ALS8 MSP ligands regulate striated muscle energy metabolism critical for adult survival in caenorhabditis elegans

   PLoS genetics·5 Sep 2013

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