UBE2M

1. UBE2M protects against lung injury in mice.

   “Ube2m deficiency exacerbated lung injury.”

   Animalselastase-induced emphysemalung

   UBE2M-mediated neddylation modification stabilizes VEGFR2 to delay pulmonary vascular endothelial cell senescence

   Cell death & disease·28 May 2026

1. UBE2M decreases cellular senescence in mouse cells.

   “UBE2M reconstitution partially alleviated cellular senescence.”

   Cellsdoxorubicin-induced endothelial cell senescence

   UBE2M-mediated neddylation modification stabilizes VEGFR2 to delay pulmonary vascular endothelial cell senescence

   Cell death & disease·28 May 2026

More on Cellular senescence

1. UBE2M increases KDR in mouse cells.

   “Mechanistic investigation confirmed that UBE2M directly regulates VEGFR2 stability in pulmonary endothelial cells via neddylation.”

   Cellsin endothelial cellslung

   UBE2M-mediated neddylation modification stabilizes VEGFR2 to delay pulmonary vascular endothelial cell senescence

   Cell death & disease·28 May 2026

More on KDR

1. UBE2M protects against vascular degeneration in mice.

   “Ube2m knockdown mice exhibited premature pulmonary aging, including vascular degeneration and structural disruption.”

   Animalsknockdown / knockoutlung

   UBE2M-mediated neddylation modification stabilizes VEGFR2 to delay pulmonary vascular endothelial cell senescence

   Cell death & disease·28 May 2026