STIL

1. STIL induces cellular senescence in mouse cells.

   “STIL overexpression induces centrosome amplification and aneuploidy, leading to senescence, apoptosis, and impaired proliferation in mouse embryonic fibroblasts”

   Cells

   STIL overexpression shortens lifespan and reduces tumor formation in mice

   PLoS genetics·28 Oct 2024

More on Cellular senescence

1. STIL shortens lifespan in mice.

   “STIL overexpression induces centrosome amplification and aneuploidy, leading to senescence, apoptosis, and impaired proliferation in mouse embryonic fibroblasts, and microcephaly with increased perinatal lethality and shortened lifespan in mice.”

   Animals

   STIL overexpression shortens lifespan and reduces tumor formation in mice

   PLoS genetics·28 Oct 2024

1. STIL lowers the risk of skin cancer in mice.

   “chemical skin carcinogenesis in animals with inducible, skin-specific STIL overexpression were reduced”

   Animalsinducible, skin-specific STIL overexpressionskin

   STIL overexpression shortens lifespan and reduces tumor formation in mice

   PLoS genetics·28 Oct 2024

More on Skin cancer

1. STIL lowers the risk of tumor in mice.

   “overall tumor formation in mice with constitutive, global STIL overexpression and chemical skin carcinogenesis in animals with inducible, skin-specific STIL overexpression were reduced”

   Animalsconstitutive, global STIL overexpression

   STIL overexpression shortens lifespan and reduces tumor formation in mice

   PLoS genetics·28 Oct 2024

More on Tumor