NEK2

2 papers3 findings

HGNC NCBI Gene Taxon

1 lab in 1 country

Animals1
Cells1

Effects

2

Cellular senescence

downin human cells1

1 study

NEK2 inhibits cellular senescence in human cells.
“NEK2 may promote the malignant progression of ESCC by inhibiting cellular senescence through the activation of the FOXM1/c-Myc/p27 signaling pathways”
Cellsin ESCC cells
NEK2 Promotes ESCC Malignant Progression by Inhibiting Cellular Senescence via the FOXM1/c-Myc/p27 Signaling Pathway
Molecular carcinogenesis6 Nov 2024

More on Cellular senescence

Tumor growth

upin mice1

1 study

NEK2 increases tumor growth in mice.
“results from in vivo experiments suggested that NEK2 knockdown can inhibit tumor growth.”
Animalsin vivo xenograft tumor model
NEK2 Promotes ESCC Malignant Progression by Inhibiting Cellular Senescence via the FOXM1/c-Myc/p27 Signaling Pathway
Molecular carcinogenesis6 Nov 2024

Associations

1

Prognosis

downin humans1

1 study

NEK2 is associated with prognosis in humans.
“NEK2 was found to be significantly upregulated, and its expression correlated with poor prognosis in ESCC patients.”
Humansin ESCC tissues
NEK2 Promotes ESCC Malignant Progression by Inhibiting Cellular Senescence via the FOXM1/c-Myc/p27 Signaling Pathway
Molecular carcinogenesis6 Nov 2024

Latest

1 in 12 months

Preprints.orgYesterday

The Centriole as a Differentiation Ratchet: A Hypothesis and an Experimental Roadmap Built on the Naturally Acentriolar Adult Cardiomyocytes of Human, Mouse and Rat

Preprint: experiments in human cellsMechanisms

Molecular Carcinogenesis6 Nov

NEK2 Promotes ESCC Malignant Progression by Inhibiting Cellular Senescence via the FOXM1/c-Myc/p27 Signaling Pathway

Experiments in miceCellular senescence