PLK4

1. PLK4 mediates centriolar architecture.

   “PLK4-mediated PTM networks regulate centriolar architecture”

   Reviewthrough post-translational modification networks

   The Centriole as the Necessary Third Mechanism of Cellular Aging

   Zenodo (CERN European Organization for Nuclear Research)·12 Apr 2026Preprint

1. Homo sapiens decrease PLK4 in human cells.

   “adult cardiomyocytes reduce their centriolar program—PLK4, CEP192, SASS6, STIL and NEK2 are all down-regulated”

   Cellsheart developmentheart

   The Centriole as a Differentiation Ratchet: A Hypothesis and an Experimental Roadmap Built on the Naturally Acentriolar Adult Cardiomyocytes of Human, Mouse and Rat

   Preprints.org·15 Oct 2026Preprint

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